Figure 5

Comparison of the NER capacities of two samples of normal breast epithelium from our BRCA1 mutation carrier patient with those of a population of disease-free controls who underwent breast reduction mammoplasty. The dark horizontal line indicates the average for the normal population of breast reduction epithelium (BRE), while the dotted lines indicate upper limits for residual NER activity in patients with the hereditary NER deficiency disease XP (0.50) and the cut-off established in our breast tissue study that identified tumors with high sensitivity and specificity (0.70). The patient sample on the left was derived from the ipsilateral (left) breast, while the sample on the right was from the contralateral (right) breast.