Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population

Table 2 Distribution of MTHFR variants in cases and controls and their association with childhood acute lymphoblastic leukemia in patients from trial ALL-BFM 2000

MTHFR	Cases (n = 443) Number (%)		Controls (n = 379) Number (%)		Odds ratio (95% CI)	P
677 CC/1298 AA	49	(11.1)	45	(11.9)	1.00^a
677 CT/1298 AA	101	(22.8)	67	(17.7)	1.38 (0.83–2.30)	0.21
677 TT/1298 AA	44	(9.9)	41	(10.8)	0.99 (0.55–1.77)	0.96
677 CC/1298 AC	101	(22.8)	87	(23.0)	1.07 (0.65–1.75)	0.80
677 CT/1298 AC	100	(22.6)	85	(22.4)	1.08 (0.66–1.78)	0.76
677 TT/1298 AC	3	(0.7)	2	(0.5)	1.38 (0.22–8.63)	0.73
677 CC/1298 CC	45	(10.2)	52	(13.7)	0.79 (0.45–1.40)	0.43
677 CT/1298 CC	n.d.		n.d.		-	-
677 TT/1298 CC	n.d.		n.d.		-	-

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