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Table 2 Genotype and allele frequencies for CYP3A4 and CYP3A5 SNPs in European and African populations. Figures in brackets are 95% confidence intervals.

From: CYP3A4 and CYP3A5genotyping by Pyrosequencing

SNP

European

African

 

na

Wild Type

Heterozygous

Variant

p

q

na

Wild Type

Heterozygous

Variant

p

q

CYP3A4*1B

93

86

7

0

0.96 (0.92–0.98)

0.04 (0.02–0.08)

88

3

25

60

0.18 (0.11–0.27)

0.82 (0.73–0.89)

CYP3A4*2

56

56

0

0

1

0

87

87

0

0

1

0

CYP3A4*3

94

90

4

0

0.98 (0.95–0.99)

0.02 (0.01–0.05)

93

93

0

0

1

0

CYP3A5*3C

95

0

12

83

0.06 (0.03–0.10)

0.94 (0.90–0.97)

95

72

23

0

0.88 (0.83–0.92)

0.12 (0.08–0.17)

CYP3A5*6

92

92

0

0

1

0

91

64

25

2

0.84 (0.78–0.89)

0.16 (0.11–0.22)

  1. an = number of passed samples out of 95 samples tested