Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1)and association with bipolar affective disorder in Taiwan

Table 4 Haplotype frequency estimation and test statistics between case and control.

Haplotype^a	Patient	Normal	Fisher's Exact Test (Pvalue)^b	OR^b,c,d	95% CI^d
TAGTAAGACA	0.340	0.359	0.755	0.919	0.61–1.38
TAGAGACCTG	0.145	0.140	1.000	1.035	0.59–1.80
GGTTGCCCTA	0.095	0.068	0.366	1.439	0.70–2.96
TAGTAACACA	0.010	0.039	0.105	0.250	0.05–1.19
TAGTAAGATA	0.025	0.010	0.278	2.615	0.50–13.64
TAGTGCGACA	0.025	0.015	0.498	1.735	0.41–7.36
GGGAGACCCA	0.025	0	0.028	--	--
TAGTAACCTG	0.020	0	0.058	--	--
TAGTGACCTG	0.020	0.010	0.443	2.081	0.38–11.49
TAGAGACATG	0.020	0.019	1.000	1.031	0.25–4.18
GGTTGCCCTG	0.020	0.010	0.443	2.082	0.38–11.49
GGTAGACCCA	0.015	0.024	0.724	0.612	0.14–2.59
Others	0.240	0.306	0.149	0.717	0.46–1.11
Total			0.082
P value of permutation test	0.602

a. The order of the markers, shown 5' → 3', is (left to right) T-1721G, A-1067G, G-347T, T3804A, G7465A, A12517C, C18626G, A20004C, C27224T, A27237G.
b. Chi-square, Fisher's Exact Test and Odds Ratio were calculated by using the SAS program.
c. The Odds Ratio could not be calculated for the haplotype GGGAGACCCA and TAGTAACCTG, because of the zero value in the population.
d. OR: odds Ratio; CI: confidence Interval.

ISSN: 1471-2350