Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1)and association with bipolar affective disorder in Taiwan

Table 3 Pairwise linkage disequilibrium indicated by the D' value (above the diagonal)^aand statistical significance indicated by the p value (below the diagonal)^bfor the ten TPH1 SNPs.

	T-1721G	A-1067G	G-347T	T3840A	G7465A	A12517C	C18626G	A20004C	C27224T	A27237G
T-1721G		1.000	0.911	0.129	0.834	0.505	0.601	0.726	0.329	0.177
A-1067G	<0.001		0.913	0.076	0.863	0.537	0.655	0.722	0.391	0.274
G-347T	<0.001	<0.001		0.121	0.840	0.450	0.645	0.655	0.447	0.032
T3840A	0.020	0.166	0.033		0.969	0.575	0.870	0.652	0.512	0.574
G7465A	<0.001	<0.001	<0.001	<0.001		0.685	0.711	0.826	0.741	0.929
A12517C	<0.001	<0.001	<0.001	<0.001	<0.001		0.684	0.320	0.663	0.039
C18626G	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001		0.765	0.684	0.780
A20004C	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001		0.624	0.625
C27224T	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001		0.956
A27237G	0.203	0.096	0.840	<0.001	<0.001	0.809	<0.001	<0.001	<0.001

^a Standardized linkage disequlibrium coefficient (absolute D' value) of Lewontin was shown.
^b Significant levels based on the chi-squared distribution to test whether the disequilibrium value differs from zero (one degree of freedom). Bold and underline indicate no significant LD at the p < 0.05 level.

ISSN: 1471-2350