Table 3 Comparison of Genotypic and Allelic Distribution of Pro12Ala polymorphism in diabetic versus non diabetic subjects. Case/Control studies show the association of the Pro12Ala polymorphism with T2D in the French Caucasian population (p = 0.04). The stratification of diabetic subjects on the obesity status shows that the association previously found is rather due to obese T2D subgroup (p = 0.03) than non obese T2D subgroup (p = 0.12).
Populations | PPAR genotypes | Allelic frequencies | P-value of allelic frequencies | |||
|---|---|---|---|---|---|---|
Pro/Pro | Pro/Ala | Ala/Ala | Pro | Ala | ||
T2D patients (n = 628) | 511 (81.4%) | 113 (18.0%) | 4 (0.6%) | 0.90 | 0.10 | P = 0.04 OR = 1.37 C.I = [1.02–1.85] |
T2D obese patients (n = 114) | 98 (86.0%) | 15 (13.1%) | 1 (0.9%) | 0.93 | 0.07 | P = 0.03 OR = 1.81 C.I = [1.05–3.13] |
T2D non obese patients (n = 503) | 403 (80.1%) | 97 (19.3%) | 3 (0.6%) | 0.90 | 0.10 | P = 0.12 OR = 1.28 C.I = [0.94–1.74] |
Non diabetic subjects (n = 318) | 246 (77.4%) | 63 (19.8%) | 9 (2.8%) | 0.87 | 0.13 | |