Table 2 Comparison of Genotypic and Allelic Distribution of Pro12Ala polymorphism in obese versus non obese subjects. Case/Control studies show that the Pro12Ala polymorphism is not associated with childhood or adult obesity in the French Caucasian population (p = 0.19, p = 0.92 respectively).
Populations | PPAR genotypes | Allelic frequencies | P-value of allelic frequencies | |||
|---|---|---|---|---|---|---|
Pro/Pro | Pro/Ala | Ala/Ala | Pro | Ala | ||
Obese children (n = 396) | 304 (76.8%) | 84 (21.2%) | 8 (2.0%) | 0.87 | 0.13 | P = 0.19 OR = 0.77 CI = [0.52–1.14] |
Lean children (n = 195) | 156 (77.9%) | 39 (21.0%) | 0 (1.1%) | 0.90 | 0.10 | |
Obese adults (n = 1102) | 857 (77.9%) | 231 (21.0%) | 12 (1.1%) | 0.88 | 0.12 | P = 0.92 OR = 1.01 CI = [0.81–1.26] |
Non obese adults (n = 611) | 478 (78.2%) | 123 (20.2%) | 10 (1.6%) | 0.88 | 0.12 | |