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Figure 2 | BMC Medical Genetics

Figure 2

From: Implication of the Pro12Ala polymorphism of the PPAR-gamma 2gene in type 2 diabetes and obesity in the French population

Figure 2

Interaction between the Pro12Ala SNP and adiposity on HOMA-IR. The interaction was tested using a GLM procedure. HOMA-IR was the dependant variable. Age, gender, BMI or obesity status, and Pro12Ala polymorphism were the explicative factors. A term of interaction BMI*Pro12Ala or obesity status*Pro12Ala was introduced. The Z score of BMI was used rather than BMI in analyses including obese children. (A) No evidence for interaction was found neither for Z score of BMI*Pro12Ala (p = 0.59) nor obesity status*Pro12Ala (p = 0.21) in 887 normal glucose tolerant lean and obese children (p = 0.58). (B) No evidence for interaction was found for BMI*Pro12Ala (p = 0.32) in 1372 normal glucose tolerant obese and lean adults subjects, but a borderline significant interaction was found for obesity status*Pro12Ala (p = 0.06).

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