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Table 4 NAT2 genotype frequency in AD cases and controls.

From: NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant

NAT2 GENOTYPE

AD CASES (N = 45)

CONTROLS (N = 63)

EXPECTED

OR (95% CI)

2*4/2*4

3 (0.07)

4 (0.06)

0.04

1.00

2*4/2*5A

1 (0.02)

4 (0.06)

0.01

0.33 (0.02, 4.74)

2*4/2*5B

6 (0.13)

10 (0.16)

0.17

0.80 (0.13, 4.87)

2*4/2*6A

6 (0.13)

4 (0.06)

0.13

2.00 (0.28, 14.20)

2*4/2*7B

1 (0.02)

0 (0)

0.01

-

2*5B/2*5B

6 (0.13)

8 (0.13)

0.18

1.00 (0.16, 6.26)

2*5B/2*5C

1 (0.02)

1 (0.02)

0.01

1.33 (0.06, 31.12)

2*5B/2*6A

16 (0.36)

25 (0.40)

0.26

0.85 (0.17, 4.33)

2*6A/2*6A

5 (0.11)

5 (0.08)

0.10

1.33 (0.19, 9.31)

2*5B/2*7B

0 (0)

1 (0.02)

0.01

-

2*5C/2*7B

0 (0)

1 (0.02)

0.00

-

Others

0 (0)

0 (0)

0.08

-

TOTAL

45 (1.00)

63 (1.00)

1.00

-

  1. The number and frequency (in brackets) of NAT2 genotypes in 45 AD cases and 63 controls is shown. Expected genotype frequency was calculated based on the allele frequency in the control group (Table 3). 'Others' includes additional NAT2 genotypes containing the alleles 2*4, 2*5A, 2*5B, 2*5C, 2*6A and 2*7B expected at low frequency which were not observed in these AD cases and controls. The OR of AD to non-disease is given with 95% CI for each NAT2 genotype (with NAT2*4/NAT2*4 as the reference group).