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Table 1 Demographic and clinical characteristics of children with ADHD separated according to COMT genotype

From: Catechol-O-Methyltransferase (COMT) Val 108/158 Metpolymorphism does not modulate executive function in children with ADHD

 

LL (23)

HL (66)

HH (29)

p-value

Gender (M/F)

20/3

52/14

29/0

χ2 = 7.39, df = 2 p = 0.02

Age

9.2 (2.0)

9.0 (1.8)

9.3 (1.7)

F2,115 = 0.21, p = 0.81

IQ

97.2 (13.7)

97.5 (13.5)

95.6 (13.8)

F2,98 = 0.17, p = 0.84

CBCL (total score)

68.0 (9.8)

70.9 (10.4)

68.9 (8.9)

F2,112 = 0.87, p = 0.42

Income (% less than 20 K)

32 %

42 %

48 %

χ2 = 1.39, df = 2 p = 0.50

DISC-IV Inattention Items

7.3 (1.5)

6.9 (2.2)

7.2 (2.3)

F2,113 = 0.46, p = 0.63

DISC-IV Hyperactivity Items

5.9 (2.4)

6.4 (2.3)

6.4 (2.7)

F2,113 = 0.33, p = 0.72

DISC-IV ADHD Subtype (I/H/C)

10/3/10

14/13/39

7/3/19

χ2 = 5.68, df = 2 p = 0.22

Comorbid ODD

13/23

50/66

20/27

χ2 = 3.21, df = 2 p = 0.20

Comorbid CD

5/23

27/64

8/27

χ2 = 3.57, df = 2 p = 0.17

Never Medicated

11/22

38/62

18/28

χ2 = 1.17, df = 2 p = 0.56

  1. CBCL = Child Behavioral Checklist. DISC-IV = Diagnostic Interview Schedule for Children fourth edition. ODD = Opposition Defiant Disorder, CD = Conduct Disorder. ADHD Subtypes: I = Inattentive, H = Hyperactive, C = Combined. Values are mean (SD).