Association of HLA class I with severe acute respiratory syndrome coronavirus infection

BMC Medical Genetics

Table 4 Effect of HLA-B* 4601 allele on severity of SARS patients

	5 deceased or intubated probable SARS patients (Severe cases)	28 Excluded fever patients					Control A 101 high risk non-infected health care workers
HLA allele	Total number of alleles (n = 10)	Total number of alleles (n = 56)	OR	CI	P	Pc-value (20)^†	Total number of alleles (n = 202)	OR	CI	P	Pc-value (33)^†
B* 4601	6	9	7.83	1.83–33.47	0.007	n.s.	25	10.62	2.80–40.26	0.0008	0.0279

n= count of alleles; P = P-value; n.s. = not significant. ^† The correction factor (number of different alleles or number of comparisons) is shown within parenthesis; Pc-value = P × Correction factor (Edward, 1974).

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