Association of HLA class I with severe acute respiratory syndrome coronavirus infection

BMC Medical Genetics

Table 2 Allele odds ratios analysis between probable SARS patients and other groups

	33 Cases Probable SARS patients	28 fever patients		Control A 101 high risk non-infected health care workers				Control B^† 190 healthy unrelated Taiwanese
HLA alleles	Total number of alleles n = 66	Total number of alleles n = 56	P	Total number of alleles n = 202	OR^†	CI	P	Total number of alleles n = 380	OR^‡	CI	P
*B 4601/B46**	15	9	n.s.	25	2.08	1.04–4.24	0.04	52	1.86	1.02–3.54	0.06
*B 1301/B13**	1	3	n.s.	18	0.16	0.02–1.00	0.03	34	0.16	0.02–0.97	0.02
*B 5401/B54**	5	3	n.s.	3	5.44	1.26–23.41	0.02	15	1.99	1.01–5.69	n.s.
*B 3901/B39**	5	2	n.s.	6	2.68	0.78–9.08	n.s.	8	3.81	1.21–12.03	0.03

P = P-value n.s. = not significant. ^† In control B, HLA-A and B were defined by serological methods. Consequently data were re-analyzed after converting allotypes of probable SARS patients to their serological equivalents [8]. ^‡Odds ratio (OR) refers to Woolf-Haldane odds ratios, with 95% Woolf approximation confidence intervals (CI) and corresponding two tails Fisher P-values. Note: No corrected P-values (Pc-values) were significant; consequently Pc-values were not indicated.

ISSN: 1471-2350