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Table 3 Comparison of plasma lipids and apoproteins levels according to alleles in CAD subjects (n. 102)

From: Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD

 

Apo E

Apo B Xba1

LIPC T202T

 

-/2 (14)

3/3 (74)

-/4 (14)

X1 (35)

X2 (67)

C carriers (39)

G carriers (65)

Total cholesterol (mg/dl)

156 ± 20

199.29

204 ± 34*

191 ± 34

206 ± 35

199 ± 41

198 ± 33

HDL-cholesterol (mg/dl)

26.8.4 ± 5.2

25.9 ± 7.1

26.76 ± 6.7

29 ± 9.6

26 ± 2.0*

34 ± 10

31.7 ± 10*

LDL-cholesterol (mg/dl)

98 ± 24

134 ± 31

141 ± 11*

138 ± 35

149 ± 36

130 ± 34

133 ± 39

Total triglycerides (mg/dl)

189.7 ± 45

178.3 ± 101

178.3 ± 80

210 ± 57

212 ± 67

170 ± 83

203 ± 81*

APO AI (mg/dl)

108.3 ± 14

105.4 ± 15

106.0 ± 10

107 ± 17

106 ± 15

119 ± 23

117 ± 22

APO AII (mg/dl)

37 ± 5.2

38 ± 6.1

38 ± 9.2

38.7 ± 6.6

38.5 ± 6.3

41 ± 8.2

41 ± 6.1

APO B (mg/dl)

77 ± 16

110 ± 19

117 ± 21*

100 ± 30

112 ± 22¶

104 ± 27

105 ± 23

APO CII (mg/dl)

4.4 ± 1.8

3.8 ± 1.6

3.7 ± 1.4

4.0 ± 1.3

3.9 ± 1.9

4.0 ± 1.6

3.9 ± 1.7

APO CIII (mg/dl)

11.6 ± 2.3

11.3 ± 2.6

12.7 ± 2.4

13.6 ± 2.1

12.3 ± 2.3

12.8 ± 2.8

12.4 ± 2.9

APO E (mg/dl)

11.0 ± 3.2

7.9 ± 1.7

8.7 ± 1.7¶

9.4 ± 2.7

9.0 ± 2.6

9.4 ± 2.6

9.3 ± 3.1

  1. Data are given as means ± SDM. Significant differences are in bold Apo E: -/2 = carriers of allele ε 2; 3/3 = homozygous carriers of allele ε 3; -/4 carriers allele ε4. *p < 0.01, ¶ p < 0.03 Apo B: X1X1 v. X1X2 + X2X2. *p < 0.01 ¶ p < 0.05 LIPC (Hepatic lipase): C allele carriers (wild type) v. G allele carriers (CG + GG) * p < 0.02; † p < 0.01 The statistical analysis of total triglycerides and LP(a) were performed on log-transformed values, but the untransformed values are given in table. After age-standardisation, continuous variables were compared by t-test and ANOVA, and categorical variables by χ2 test
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BMC Medical Genetics

ISSN: 1471-2350

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