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Table 1 Characteristics of Index Patients with CVID and IgGSD.1

From: HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama

Characteristic CVID (n = 114) IgGSD (n = 126)
Men: Women 32: 82 38: 88
Age at Diagnosis, y (range) 54 ± 16 (21 – 87) 51 ± 13 (18 – 89)
Serum Total IgG, mg/dL (range) 527 ± 115 (140 – 697) 953 ± 199 (700 – 1751)
Deficient IgG Subclass(es) Percentage (n) Percentage (n)
1, 3 38.6 (44) 8.7 (11)
1 16.7 (19) 17.5 (22)
1, 2, 3 12.3 (14) 0
3 7.0 (8) 52.4 (66)
1, 2 7.0 (8) 0
1, 3, 4 7.0 (8) 0
1, 4 5.3 (6) 3.2 (4)
2, 3 3.5 (4) 1.6 (2)
1, 2, 3, 4 2.6 (3) 0
2 0.9 (1) 3.2 (4)
1, 2, 4 0.9 (1) 0
4 0 7.9 (10)
3, 4 0 4.8 (6)
2, 3, 4 0 0.8 (1)
Index Patients with Serum IgA Deficiency, % (n) 21.1 (24) 9.5 (12)
Index Patients with Serum IgM Deficiency, % (n) 18.4 (21) 7.9 (10)
  1. 1 By definition, all probands with CVID had subnormal serum concentrations of total IgG at diagnosis; mean serum IgG concentrations were significantly lower in CVID (p < 0.000.1; two-tail t-test). The percentage of index patients with IgA deficiency was significantly greater in CVID (p = 0.0293; Chi-square test). The percentage of index patients with IgM deficiency was significantly greater in CVID (p = 0.0156; Chi-square test).