HLA-A and -B alleles and haplotypes in hemochromatosis probands with HFEC282Y homozygosity in central Alabama

BMC Medical Genetics

Table 1 Phenotype Frequencies of HLA-A Alleles in Alabama Subjects.¹

A* Alleles	Frequency in 139 Hemochromatosis Probands	Frequency in Control Subjects (n)	Odds Ratio
01	0.2014²	0.3397 (1,319)	0.5
02	0.3021²	0.5206 (1,310)	0.4
03	0.7482³	0.2739 (1,318)	7.9
11	0.1007	0.1136 (1,320)	0.9
23	0.0288	0.0375 (1,254)	0.9
24	0.0719	0.1304 (1,265)	0.5
25	0.0432	0.0297 (1,281)	1.5
26	0.0216	0.0634 (1,278)	0.3
28	0.0504	0.0773 (1,320)	0.6
29	0.0432	0.0620 (1,290)	0.7
30	0.0144	0.0405 (1,308)	0.4
31	0.0216	0.0350 (1,258)	0.6
32	0. 0216	0.0536 (1,232)	0.4
33	0. 0216	0.0176 (1,248)	1.2

¹Alleles were detected using low-resolution DNA-based typing in hemochromatosis probands and microlymphocytotoxcity in control subjects. ²These frequencies were significantly lower in hemochromatosis probands than in control subjects (A*01, p = 0.0013; A*02, p < 0.0001). ³This frequency in hemochromatosis probands was significantly greater in probands than in control subjects (p < 0.0001).

ISSN: 1471-2350