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Table 1 Genes with increased levels of expression in at least 3 of 4 mutant MeCP2 expressing clonal fibroblast cell strains when compared to matched clonal wild type MeCP2 expressing cell strains

From: Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations

GenBank Accession Expression In Brain Gene Symbol/UniGene No. Gene Name Function
J00123 x HUMENK2 Human enkephalin gene neuropeptide
AW007146 x SYTL2 Synaptotagmin-like 2 neurotransmission
AF051850   SVIL Supervillin link between cytoskeleton and membrane
AA447177   Hs.202101 Beta syntrophina cytoskeletal protein
M13509 x MMP1 Matrix metalloproteinase 1 (interstitial collagenase) breakdown of extracellular matrix
X05232   MMP3 Matrix metalloproteinase 3 (stromelysin 1, progelatinase) breakdown of extracellular matrix
X07820   MMP10 Matrix metalloproteinase 10 (stromelysin 2) breakdown of extracellular matrix
AB011153 x PLCB1 Phospholipase C, beta 1 (phosphoinositide-specific) phospholipase
M72393   PLA2G4A Phospholipase A2, group IVA (cytosolic, calcium-dependent) phospholipase
AW015590 x RGC32 RGC32 protein extracellular matrix protein
AW007426 x SPON2 Spondin 2, extracellular matrix protein extracellular matrix protein
AA401504   VSHK1 Orphan seven-transmembrane receptor, chemokine related chemokine receptor
AI131555   VSHK1 Orphan seven-transmembrane receptor, chemokine related chemokine receptor
AF037335 x CA12 Carbonic anhydrase XII zinc metalloenzyme
AI050855 x CA12 Carbonic Anhydrase XIIa zinc metalloenzyme
AI681917 x Hs.3321 Iriquois related homeobox 3 related proteina transcription factor
AF047419 x TCF21 Transcription factor 21 transcription factor
U01244 x FBLN1 Fibulin 1 secreted glycoprotein (extracellular matrix)
X60708 x DPP4 Dipeptidylpeptidase IV membrane glycoprotein
M14058 x C1R Complement component 1, r subcomponent serine protease (complement pathway)
X90392 x DNASE1L1 Deoxyribonuclease I-like 1 DNAse
Y17782   HSBP3 Heat shock 27 kD protein 3 heat shock protein
AF058056   SLC16A7 Solute carrier family 16 (monocarboxylic acid transporters), member 7 monocarboxylate transport family member
X04430   IL6 Interleukin 6 (interferon, beta 2) induces maturation of B cells
U81607 x AKAP12 A kinase (PRKA) anchor protein (gravin) 12 kinase anchor protein
D28915 x MTAP44 Interferon-induced, hepatitis C-associated microtubular aggregate protein member of interferon inducible proteins
M34057 x LTBP1 Latent transforming growth factor beta binding protein 1 assembly of TGF beta
AL050227 x Hs.27860 Prostaglandin E2 receptor, EP3 Subtypea prostaglandin receptor
W31022 x Hs.48376 TRADEbetaa tumor necrosis factor signaling
AI669308 x BID BH3 interacting domain death agonist cell death regulation
W95076   Hs.271639 RSK-like proteina signal transduction
AI752682 x NTN4 Netrin 4 leukocyte adhesion
M97935 x STAT1 Signal transducer and activator of transcription 1, 91 kD signal transduction
AI338491   Hs.209209 CALD 1 – caldesmon 1a cytoskeletal regulator
M33197 x GAPDH Glyceraldehyde-3-phosphate dehydrogenase carbohydrate metabolism
AA625449 x Hs.238532 N-acetylgalactosaminyltransferase 7a glycosylation
AI189112 x Hs.65366   
AI809872 x Hs.19669   
AI949749   Hs.44441   
AI884906 x Hs.111164   
AI984197 x Hs.16064   
AI307802 x Hs.135560   
AI806221 x Hs.38022   
AI018671   Hs.93701   
N48346 x Hs.125489   
AA426500   Hs.85989   
N40767   Hs.6786   
AB002365 x Hs.23311   
AL080058 x Hs.6909   
  1. aIdentified in Celera database