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Table 1 Genes with increased levels of expression in at least 3 of 4 mutant MeCP2 expressing clonal fibroblast cell strains when compared to matched clonal wild type MeCP2 expressing cell strains
| GenBank Accession | Expression In Brain | Gene Symbol/UniGene No. | Gene Name | Function |
|---|---|---|---|---|
| J00123 | x | HUMENK2 | Human enkephalin gene | neuropeptide |
| AW007146 | x | SYTL2 | Synaptotagmin-like 2 | neurotransmission |
| AF051850 | SVIL | Supervillin | link between cytoskeleton and membrane | |
| AA447177 | Hs.202101 | Beta syntrophina | cytoskeletal protein | |
| M13509 | x | MMP1 | Matrix metalloproteinase 1 (interstitial collagenase) | breakdown of extracellular matrix |
| X05232 | MMP3 | Matrix metalloproteinase 3 (stromelysin 1, progelatinase) | breakdown of extracellular matrix | |
| X07820 | MMP10 | Matrix metalloproteinase 10 (stromelysin 2) | breakdown of extracellular matrix | |
| AB011153 | x | PLCB1 | Phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase |
| M72393 | PLA2G4A | Phospholipase A2, group IVA (cytosolic, calcium-dependent) | phospholipase | |
| AW015590 | x | RGC32 | RGC32 protein | extracellular matrix protein |
| AW007426 | x | SPON2 | Spondin 2, extracellular matrix protein | extracellular matrix protein |
| AA401504 | VSHK1 | Orphan seven-transmembrane receptor, chemokine related | chemokine receptor | |
| AI131555 | VSHK1 | Orphan seven-transmembrane receptor, chemokine related | chemokine receptor | |
| AF037335 | x | CA12 | Carbonic anhydrase XII | zinc metalloenzyme |
| AI050855 | x | CA12 | Carbonic Anhydrase XIIa | zinc metalloenzyme |
| AI681917 | x | Hs.3321 | Iriquois related homeobox 3 related proteina | transcription factor |
| AF047419 | x | TCF21 | Transcription factor 21 | transcription factor |
| U01244 | x | FBLN1 | Fibulin 1 | secreted glycoprotein (extracellular matrix) |
| X60708 | x | DPP4 | Dipeptidylpeptidase IV | membrane glycoprotein |
| M14058 | x | C1R | Complement component 1, r subcomponent | serine protease (complement pathway) |
| X90392 | x | DNASE1L1 | Deoxyribonuclease I-like 1 | DNAse |
| Y17782 | HSBP3 | Heat shock 27 kD protein 3 | heat shock protein | |
| AF058056 | SLC16A7 | Solute carrier family 16 (monocarboxylic acid transporters), member 7 | monocarboxylate transport family member | |
| X04430 | IL6 | Interleukin 6 (interferon, beta 2) | induces maturation of B cells | |
| U81607 | x | AKAP12 | A kinase (PRKA) anchor protein (gravin) 12 | kinase anchor protein |
| D28915 | x | MTAP44 | Interferon-induced, hepatitis C-associated microtubular aggregate protein | member of interferon inducible proteins |
| M34057 | x | LTBP1 | Latent transforming growth factor beta binding protein 1 | assembly of TGF beta |
| AL050227 | x | Hs.27860 | Prostaglandin E2 receptor, EP3 Subtypea | prostaglandin receptor |
| W31022 | x | Hs.48376 | TRADEbetaa | tumor necrosis factor signaling |
| AI669308 | x | BID | BH3 interacting domain death agonist | cell death regulation |
| W95076 | Hs.271639 | RSK-like proteina | signal transduction | |
| AI752682 | x | NTN4 | Netrin 4 | leukocyte adhesion |
| M97935 | x | STAT1 | Signal transducer and activator of transcription 1, 91 kD | signal transduction |
| AI338491 | Hs.209209 | CALD 1 – caldesmon 1a | cytoskeletal regulator | |
| M33197 | x | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | carbohydrate metabolism |
| AA625449 | x | Hs.238532 | N-acetylgalactosaminyltransferase 7a | glycosylation |
| AI189112 | x | Hs.65366 | ||
| AI809872 | x | Hs.19669 | ||
| AI949749 | Hs.44441 | |||
| AI884906 | x | Hs.111164 | ||
| AI984197 | x | Hs.16064 | ||
| AI307802 | x | Hs.135560 | ||
| AI806221 | x | Hs.38022 | ||
| AI018671 | Hs.93701 | |||
| N48346 | x | Hs.125489 | ||
| AA426500 | Hs.85989 | |||
| N40767 | Hs.6786 | |||
| AB002365 | x | Hs.23311 | ||
| AL080058 | x | Hs.6909 |
