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Table 1 Genes with increased levels of expression in at least 3 of 4 mutant MeCP2 expressing clonal fibroblast cell strains when compared to matched clonal wild type MeCP2 expressing cell strains

From: Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations

GenBank Accession

Expression In Brain

Gene Symbol/UniGene No.

Gene Name

Function

J00123

x

HUMENK2

Human enkephalin gene

neuropeptide

AW007146

x

SYTL2

Synaptotagmin-like 2

neurotransmission

AF051850

 

SVIL

Supervillin

link between cytoskeleton and membrane

AA447177

 

Hs.202101

Beta syntrophina

cytoskeletal protein

M13509

x

MMP1

Matrix metalloproteinase 1 (interstitial collagenase)

breakdown of extracellular matrix

X05232

 

MMP3

Matrix metalloproteinase 3 (stromelysin 1, progelatinase)

breakdown of extracellular matrix

X07820

 

MMP10

Matrix metalloproteinase 10 (stromelysin 2)

breakdown of extracellular matrix

AB011153

x

PLCB1

Phospholipase C, beta 1 (phosphoinositide-specific)

phospholipase

M72393

 

PLA2G4A

Phospholipase A2, group IVA (cytosolic, calcium-dependent)

phospholipase

AW015590

x

RGC32

RGC32 protein

extracellular matrix protein

AW007426

x

SPON2

Spondin 2, extracellular matrix protein

extracellular matrix protein

AA401504

 

VSHK1

Orphan seven-transmembrane receptor, chemokine related

chemokine receptor

AI131555

 

VSHK1

Orphan seven-transmembrane receptor, chemokine related

chemokine receptor

AF037335

x

CA12

Carbonic anhydrase XII

zinc metalloenzyme

AI050855

x

CA12

Carbonic Anhydrase XIIa

zinc metalloenzyme

AI681917

x

Hs.3321

Iriquois related homeobox 3 related proteina

transcription factor

AF047419

x

TCF21

Transcription factor 21

transcription factor

U01244

x

FBLN1

Fibulin 1

secreted glycoprotein (extracellular matrix)

X60708

x

DPP4

Dipeptidylpeptidase IV

membrane glycoprotein

M14058

x

C1R

Complement component 1, r subcomponent

serine protease (complement pathway)

X90392

x

DNASE1L1

Deoxyribonuclease I-like 1

DNAse

Y17782

 

HSBP3

Heat shock 27 kD protein 3

heat shock protein

AF058056

 

SLC16A7

Solute carrier family 16 (monocarboxylic acid transporters), member 7

monocarboxylate transport family member

X04430

 

IL6

Interleukin 6 (interferon, beta 2)

induces maturation of B cells

U81607

x

AKAP12

A kinase (PRKA) anchor protein (gravin) 12

kinase anchor protein

D28915

x

MTAP44

Interferon-induced, hepatitis C-associated microtubular aggregate protein

member of interferon inducible proteins

M34057

x

LTBP1

Latent transforming growth factor beta binding protein 1

assembly of TGF beta

AL050227

x

Hs.27860

Prostaglandin E2 receptor, EP3 Subtypea

prostaglandin receptor

W31022

x

Hs.48376

TRADEbetaa

tumor necrosis factor signaling

AI669308

x

BID

BH3 interacting domain death agonist

cell death regulation

W95076

 

Hs.271639

RSK-like proteina

signal transduction

AI752682

x

NTN4

Netrin 4

leukocyte adhesion

M97935

x

STAT1

Signal transducer and activator of transcription 1, 91 kD

signal transduction

AI338491

 

Hs.209209

CALD 1 – caldesmon 1a

cytoskeletal regulator

M33197

x

GAPDH

Glyceraldehyde-3-phosphate dehydrogenase

carbohydrate metabolism

AA625449

x

Hs.238532

N-acetylgalactosaminyltransferase 7a

glycosylation

AI189112

x

Hs.65366

  

AI809872

x

Hs.19669

  

AI949749

 

Hs.44441

  

AI884906

x

Hs.111164

  

AI984197

x

Hs.16064

  

AI307802

x

Hs.135560

  

AI806221

x

Hs.38022

  

AI018671

 

Hs.93701

  

N48346

x

Hs.125489

  

AA426500

 

Hs.85989

  

N40767

 

Hs.6786

  

AB002365

x

Hs.23311

  

AL080058

x

Hs.6909

  
  1. aIdentified in Celera database