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Figure 1 | BMC Medical Genetics

Figure 1

From: Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations

Figure 1

MECP2 transcript sequence and GeneScan™ results for the human androgen receptor (AR) polymorphism used to determine X chromosome inactivation patterns. A. Parental cell strain with 916C>T (R306C) mutation and mosaic X-inactivation with expression of 285 bp and 288 bp AR alleles. B. Fibroblast clone from R306C donor expresses MECP2 transcript with mutant T allele and carries the 288 bp AR allele on the inactive X chromosome. C. Fibroblast clone from R306C donor expresses MECP2 transcript with normal C allele and carries the 285 bp AR allele on the inactive X chromosome.

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