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Table 2 VDR-FokI polymorphism in study subjects analyzed with respect to GAD65 antibody status

From: Vitamin D receptor initiation codon polymorphism influences genetic susceptibility to type 1 diabetes mellitus in the Japanese population

  GAD65-positive GAD65-negative Controls
  T1DM T1DM  
  n = 48 n = 30 n = 250
Genotype frequenciesa    
   FF 26 (54%) 10(33%) 82 (33%)
   Ff 19 (40%) 18(60%) 138 (55%)
   ff 3(6%) 2(7%) 30 (12%)
Allele frequenciesb    
   F 71 (74%) 38(63%) 302(60%)
   f 25 (26%) 22(37%) 198(40%)
Phenotype frequenciesc    
   F positive 45 (94%) 28 (94%) 220(88%)
   f positive 22 (46%) 20 (67%) 168(67%)
  1. Values shown are the number of subjects with the percentage in parentheses. aΧ2 test of heterogeneity between GAD65-positive T1DM patients and control subjects. Χ2 = 8.14, 2 degrees of freedom; P = 0.017. bΧ2 test of heterogeneity between GAD65-positive T1DM patients and control subjects. Χ2 = 6.32, 1 degree of freedom; P = 0.012. cRelative risk ratio for F phenotype (GAD65-positive T1DM) = 2.0.