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Table 2 VDR-FokI polymorphism in study subjects analyzed with respect to GAD65 antibody status

From: Vitamin D receptor initiation codon polymorphism influences genetic susceptibility to type 1 diabetes mellitus in the Japanese population

 

GAD65-positive

GAD65-negative

Controls

 

T1DM

T1DM

 
 

n = 48

n = 30

n = 250

Genotype frequenciesa

   

   FF

26 (54%)

10(33%)

82 (33%)

   Ff

19 (40%)

18(60%)

138 (55%)

   ff

3(6%)

2(7%)

30 (12%)

Allele frequenciesb

   

   F

71 (74%)

38(63%)

302(60%)

   f

25 (26%)

22(37%)

198(40%)

Phenotype frequenciesc

   

   F positive

45 (94%)

28 (94%)

220(88%)

   f positive

22 (46%)

20 (67%)

168(67%)

  1. Values shown are the number of subjects with the percentage in parentheses. aΧ2 test of heterogeneity between GAD65-positive T1DM patients and control subjects. Χ2 = 8.14, 2 degrees of freedom; P = 0.017. bΧ2 test of heterogeneity between GAD65-positive T1DM patients and control subjects. Χ2 = 6.32, 1 degree of freedom; P = 0.012. cRelative risk ratio for F phenotype (GAD65-positive T1DM) = 2.0.
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