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Table 3 Allele and genotype distribution of the Ala(-9)Val SOD2 polymorphic marker in type 1 diabetic patients with and without neuropathy

From: Polymorphisms in the Mn-SOD and EC-SOD Genes and Their Relationship to Diabetic Neuropathy in Type 1 Diabetes Mellitus

Group

Allele frequency n (%)

Genotype frequency n (%)

 

Ala

Val

Ala/Ala

Ala/Val

Val/Val

Neuropathy (n = 82)

83a (50.6)

81b (49.4)

14c (17.1)

55 (67.0)

13d (15.9)

No neuropathy (n = 84)

115 (68.5)

53 (31.5)

33 (39.3)

49 (58.3)

2 (2.4)

  1. a Ala allele frequency was significantly lower in patients with diabetic neuropathy than in subjects without this complication (odds ratio = 0.48, p = 0.00067, pc = 0.00134). b Val allele frequency was significantly higher in patients with diabetic neuropathy than in subjects without this complication (odds ratio = 2.10, p = 0.00067, pc = 0.00134). c Ala/Ala genotype frequency was significantly lower in patients with diabetic neuropathy than in subjects without this complication (odds ratio = 0.34, p = 0.00122, pc = 0.00366). d Val/Val genotype frequency was significantly higher in patients with diabetic neuropathy tha in subjects without this complication (odds ratio = 5.10, p = 0.00219, pc = 0.00657).