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Table 3 Allele and genotype distribution of the Ala(-9)Val SOD2 polymorphic marker in type 1 diabetic patients with and without neuropathy

From: Polymorphisms in the Mn-SOD and EC-SOD Genes and Their Relationship to Diabetic Neuropathy in Type 1 Diabetes Mellitus

Group Allele frequency n (%) Genotype frequency n (%)
  Ala Val Ala/Ala Ala/Val Val/Val
Neuropathy (n = 82) 83a (50.6) 81b (49.4) 14c (17.1) 55 (67.0) 13d (15.9)
No neuropathy (n = 84) 115 (68.5) 53 (31.5) 33 (39.3) 49 (58.3) 2 (2.4)
  1. a Ala allele frequency was significantly lower in patients with diabetic neuropathy than in subjects without this complication (odds ratio = 0.48, p = 0.00067, pc = 0.00134). b Val allele frequency was significantly higher in patients with diabetic neuropathy than in subjects without this complication (odds ratio = 2.10, p = 0.00067, pc = 0.00134). c Ala/Ala genotype frequency was significantly lower in patients with diabetic neuropathy than in subjects without this complication (odds ratio = 0.34, p = 0.00122, pc = 0.00366). d Val/Val genotype frequency was significantly higher in patients with diabetic neuropathy tha in subjects without this complication (odds ratio = 5.10, p = 0.00219, pc = 0.00657).