Linkage analysis of HLA and candidate genes for celiac disease in a North American family-based study

BMC Medical Genetics

Table 2 Two-point and Multi-point HLODs at Markers for HLA and 13 Candidate Genes

Candidate gene	Chromosome	Position (cM)	Marker	Number families ^*	Model	Best two-point HLOD (α/θ)+	Positive multi-point HLOD(α)
CD4	12pter-pl2	16.4	CD4	44	Rec	0.0
CTLA-4	2q33	198.7	CTLA4A/G	36	Dom/Rec	0.0
		198.7	CTLA4-STR	48	Dom/Rec	0.0
IDDM3	15q26	109.3	D15S107	47	Dom	0.14 (0.15/0.0)	0
		115.9	D15S87	47	Dom	0.0
IDDM4	11q13	85.5	GATA30G01	47	Dom	0.29 (1.00/0.40)
IDDM5	6q25	146.1	GATA184A08	35	Dom/Rec	0.0	0.19(0.13) @ 154 cM
		154.1	D6S441	45	Rec	0.15 (1.00/0.3)
		154.6	GATA165G02	46	Dom/Rec	0.0
IDDM6	18q21	84.8	D18S64	41	Dom/Rec	0.0
IDDM7	6q27	173.3	D6S1277	39	Dom/Rec	0.0
		187.2	D6S1027	40	Dom/Rec	0.0
IDDM9	3q22-q25	126.8	D3S3044	46	Rec	0.84 (0.05/0.0)	0.03(0.03) @ 127 cM
		133.9	D3S1558	54	Rec	0.02 (0.05/0.1)
IDDM10	10p11-q11	70.2	D10S220	45	Dom	0.69 (1.00/0.20)
TCRα	14q11.2	6.5	D14S261	43	Dom	0.34 (1.00/0.30)
and		13.9	D14S283	44	Dom	0.18 (1.00/0.40)
TCRδ		22.7	D14S64	37	Dom	0.34 (1.00/0.30)
TCRβ	7q35	144.7	D7S495	45	Rec	0.25 (1.00/0.30)	0.42(0.19)@145 cM
		155.1	D7S794	48	Rec	0.66 (1.00/0.20)
		162.3	D7S636	37	Rec	0
TCRγ	7p15-p14	28.7	D7S507	51	Rec	0.01 (0.80/0.40)	0
		34.7	D7S493	39	Rec	0.24 (1.00/0.30)
		39.8	D7S529	56	Rec	0.0
		41.7	D7S1808	49	Rec	0.0
HLA	6p21.3	44.4	D6S276	34	Dom	1.48 (0.95/0.10)	5.02 (0.66) @ 55 cM
		49.5	D6S291	35	Dom	1.60 (1.00/0.10)
		60.4	D6S426	28	Dom	3.10 (1.00/0.10)
		66.4	D6S282	30	Dom	1.52 (0.45/0.00)

^*There were a total of 62 families, however not all families were genotyped for all markers or missing genotypes precluded analysis in the family. + α = proportion of families linked ; θ = recombination fraction; Best HLOD from the analyses of dominant and recessive models

ISSN: 1471-2350