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Table 3 Comparison of BMI and of metabolic parameters according to theTNF-α genotypes

From: The G-308A variant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distribution

 

Total subjects

 
 

GG

GA + AA

p-value

 

(n. = 145)

(n = 49)

 

Age (yrs)

48.9 ± 1.3

49.4 ± 1.8

NS

Body Mass Index (kg/m2)

31.6 ± 0.6

29.1 ± 0.7

<0.05*

Blood glucose (mmol/L)

5.06 ± 01

4.79 ± 0.2

NS

Fasting plasma insulin (μU/ml)

18.9 ± 1.5

21.4 ± 3.8

NS

HOMA IIR

4.34 ± 0.3

4.79 ± 0.2

NS

Plasma lipids (mmol/L)

   

   Total cholesterol

219.0 ± 4.4

214.4 ± 6.8

NS

   Total triglycerides

154.2 ± 11.4

156.1 ± 15.6

NS

   HDL cholesterol

48.5 ± 1.4

47.2 ± 2.8

NS

   LDL cholesterol

132.5 ± 4.1

127.3 ± 7.1

NS

  1. Data are given as means ± SEM. All p-values were corrected for differences in age GG, GA, and AA = TNF-α genotypes. * p-value after correction = not significant. The statistical analysis of total triglycerides and plasma insulin were performed on log-trasformed values, but the untrasformed values are given in table. Continuous variables were compared by t-test and categorical variables by Χ2 test.
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BMC Medical Genetics

ISSN: 1471-2350

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