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Table 3 Comparison of BMI and of metabolic parameters according to theTNF-α genotypes

From: The G-308A variant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distribution

  Total subjects  
  GG GA + AA p-value
  (n. = 145) (n = 49)  
Age (yrs) 48.9 ± 1.3 49.4 ± 1.8 NS
Body Mass Index (kg/m2) 31.6 ± 0.6 29.1 ± 0.7 <0.05*
Blood glucose (mmol/L) 5.06 ± 01 4.79 ± 0.2 NS
Fasting plasma insulin (μU/ml) 18.9 ± 1.5 21.4 ± 3.8 NS
HOMA IIR 4.34 ± 0.3 4.79 ± 0.2 NS
Plasma lipids (mmol/L)    
   Total cholesterol 219.0 ± 4.4 214.4 ± 6.8 NS
   Total triglycerides 154.2 ± 11.4 156.1 ± 15.6 NS
   HDL cholesterol 48.5 ± 1.4 47.2 ± 2.8 NS
   LDL cholesterol 132.5 ± 4.1 127.3 ± 7.1 NS
  1. Data are given as means ± SEM. All p-values were corrected for differences in age GG, GA, and AA = TNF-α genotypes. * p-value after correction = not significant. The statistical analysis of total triglycerides and plasma insulin were performed on log-trasformed values, but the untrasformed values are given in table. Continuous variables were compared by t-test and categorical variables by Χ2 test.