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Table 2 Genotype distributions and allele frequencies for G-308A mutation in theTNF-α gene in obese subjects and controls

From: The G-308A variant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distribution

   Genotypes Allele frequencies
  n. GG GA AA G A
Total obese subjects* 115 87 (75.6%) 26 (22.6%) 2 (1.8%) 0.869 0.131
   – Central obesity # 61 50 (81.9%) 11 (18,1%) - 0.909 0.091
   – Peripheral obesity § 37 28 (75.6%) 9 (24.4) - 0.878 0.122
Lean subjects 79 58 (73.4%) 19 (24.%) 2 (2.%) 0.854 0.146
  1. GG, GA, and AA = TNF-α genotypes. Total obese subjects includes 17 patients whom did not undergo biolectric impedance analysis * Total obese subjects vs controls: genotypes Χ2 = 0.21, df = 2, p < NS; allele frequencies Χ2 = 0.09, df = 1, p < NS. # Central obese subjects vs controls: genotypes Χ2 = 2.4, df = 2, p < NS; allele frequencies Χ2 = 1.4, df = 1, p < NS. § Peripheral obese subjects vs controls: genotypes Χ2 = 0.95, df = 2, p < NS; allele frequencies Χ2 = 0.16, df = 1, p < NS. Central obese subjects vs peripheral obese subjects: genotypes Χ2 = 0.5, df = 1, p = NS; allele frequencies Χ2 = 0.4, df = 1, p = NS. Cutpoints for centrally obese subjects were : WC 94 for men and WC 88 for women
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BMC Medical Genetics

ISSN: 1471-2350

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