Table 3 The associations of the CHI3L1 rs1538372 and rs10399931 polymorphisms with clinical status and characteristics in asthma and control groups

Age (year)

51.40 ± 14.26

51.14 ± 14.08

52.91 ± 13.91

0.66

50.00 ± 11.86

50.78 ± 11.64

50.22 ± 12.58

0.743

Sex

  Male

120 (44.4%)

142 (48.5%)

27 (41.5%)

0.472

108 (47.8%)

141 (45.3%)

40 (44.0%)

0.779

  Female

150 (55.6%)

151(51.5%)

38 (58.5%)

118 (52.2%)

170 (54.7%)

51 (56.0%)

BMI (kg/m²)

25.31 ± 4.25

25.3 ± 3.93

25.00 ± 3.92

0.846

23.85 ± 3.54

23.88 ± 3.31

24.47 ± 3.36

0.332

WC (cm)

86.70 ± 12.00

87.18 ± 10.83

86.74 ± 8.89

0.888

79.21 ± 10.20

77.67 ± 9.03

80.06 ± 9.02

0.113

WHR

0.88 ± 0.09

0.88 ± 0.08

0.87 ± 0.06

0.764

0.83 ± 0.10

0.81 ± 0.07

0.82 ± 0.07

0.041

IgE (IU/mL)

279.24 ± 648.79

221.09 ± 399.22

375.48 ± 913.44

0.7^a

111.64 ± 190.17

137.02 ± 337.76

140.32 ± 336.82

0.619^a

YKL-40 (ng/mL)

130.00 ± 126.89

103.79 ± 101.13

81.18 ± 69.18

< 0.0001^a

115.47 ± 128.54

88.441 ± 84.23

68.32 ± 61.35

0.011^a

FEV1%, pred

84.00 ± 20.66

79.71 ± 21.73

79.26 ± 23.42

0.046

91.91 ± 17.46

93.36 ± 15.64

88.75 ± 15.88

0.16

FVC%, pred

87.47 ± 21.03

84.32 ± 20.40

84.94 ± 25.67

0.216

97.08 ± 16.90

97.52 ± 17.78

97.54 ± 15.01

0.97

rs10399931

GG (N = 270)

GA (N = 286)

AA (N = 72)

P value

GG (N = 229)

GA (N = 307)

AA (N = 90)

P value

Age (year)

51.28 ± 14.14

51.16 ± 14.06

53.13 ± 14.41

0.557

50.32 ± 11.63

50.32 ± 11.79

50.97 ± 12.72

0.892

Sex

  Male

122 (45.2%)

136 (47.6%)

31 (43.1%)

0.741

112 (48.9%)

136 (44.3%)

40 (44.4%)

0.542

  Female

148 (54.8%)

150 (52.4%)

41 (56.9%)

117 (51.1%)

171 (55.7%)

50 (55.6%)

BMI (kg/m²)

25.24 ± 4.29

25.36 ± 3.87

25.06 ± 4.04

0.843

23.82 ± 3.33

23.96 ± 3.46

24.16 ± 3.34

0.723

WC (cm)

86.54 ± 11.91

87.08 ± 10.87

87.78 ± 9.47

0.712

78.84 ± 9.71

78.08 ± 9.50

79.40 ± 9.01

0.534

WHR

0.87 ± 0.09

0.88 ± 0.08

0.88 ± 0.07

0.942

0.83 ± 0.10

0.82 ± 0.07

0.82 ± 0.07

0.399

IgE (IU/mL)

276.80 ± 645.41

229.82 ± 454.97

331.63 ± 768.03

0.613

95.65 ± 155.72

150.11 ± 346.92

139.44 ± 351.86

0.511

YKL-40 (ng/mL)

133.08 ± 128.56

99.16 ± 89.75

90.66 ± 109.85

< 0.0001^a

105.15 ± 103.82

98.89 ± 108.91

63.403 ± 57.64

0.009^a

FEV1%, pred

83.20 ± 20.89

80.96 ± 22.16

77.41 ± 21.05

0.116

92.81 ± 18.37

92.91 ± 14.58

88.30 ± 16.71

0.127

FVC%, pred

86.79 ± 20.83

85.09 ± 21.67

84.44 ± 21.79

0.562

98.69 ± 18.26

96.42 ± 16.31

97.18 ± 16.48

0.463