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Table 3 The associations of the CHI3L1 rs1538372 and rs10399931 polymorphisms with clinical status and characteristics in asthma and control groups

From: CHI3L1polymorphisms associate with asthma in a Taiwanese population

  Asthma Control
rs1538372 CC (N = 270) CT (N = 293) TT (N = 65) P value CC (N = 226) CT (N = 311) TT (N = 91) P value
Age (year) 51.40 ± 14.26 51.14 ± 14.08 52.91 ± 13.91 0.66 50.00 ± 11.86 50.78 ± 11.64 50.22 ± 12.58 0.743
Sex         
  Male 120 (44.4%) 142 (48.5%) 27 (41.5%) 0.472 108 (47.8%) 141 (45.3%) 40 (44.0%) 0.779
  Female 150 (55.6%) 151(51.5%) 38 (58.5%)   118 (52.2%) 170 (54.7%) 51 (56.0%)  
BMI (kg/m2) 25.31 ± 4.25 25.3 ± 3.93 25.00 ± 3.92 0.846 23.85 ± 3.54 23.88 ± 3.31 24.47 ± 3.36 0.332
WC (cm) 86.70 ± 12.00 87.18 ± 10.83 86.74 ± 8.89 0.888 79.21 ± 10.20 77.67 ± 9.03 80.06 ± 9.02 0.113
WHR 0.88 ± 0.09 0.88 ± 0.08 0.87 ± 0.06 0.764 0.83 ± 0.10 0.81 ± 0.07 0.82 ± 0.07 0.041
IgE (IU/mL) 279.24 ± 648.79 221.09 ± 399.22 375.48 ± 913.44 0.7a 111.64 ± 190.17 137.02 ± 337.76 140.32 ± 336.82 0.619a
YKL-40 (ng/mL) 130.00 ± 126.89 103.79 ± 101.13 81.18 ± 69.18 < 0.0001a 115.47 ± 128.54 88.441 ± 84.23 68.32 ± 61.35 0.011a
FEV1%, pred 84.00 ± 20.66 79.71 ± 21.73 79.26 ± 23.42 0.046 91.91 ± 17.46 93.36 ± 15.64 88.75 ± 15.88 0.16
FVC%, pred 87.47 ± 21.03 84.32 ± 20.40 84.94 ± 25.67 0.216 97.08 ± 16.90 97.52 ± 17.78 97.54 ± 15.01 0.97
rs10399931 GG (N = 270) GA (N = 286) AA (N = 72) P value GG (N = 229) GA (N = 307) AA (N = 90) P value
Age (year) 51.28 ± 14.14 51.16 ± 14.06 53.13 ± 14.41 0.557 50.32 ± 11.63 50.32 ± 11.79 50.97 ± 12.72 0.892
Sex         
  Male 122 (45.2%) 136 (47.6%) 31 (43.1%) 0.741 112 (48.9%) 136 (44.3%) 40 (44.4%) 0.542
  Female 148 (54.8%) 150 (52.4%) 41 (56.9%)   117 (51.1%) 171 (55.7%) 50 (55.6%)  
BMI (kg/m2) 25.24 ± 4.29 25.36 ± 3.87 25.06 ± 4.04 0.843 23.82 ± 3.33 23.96 ± 3.46 24.16 ± 3.34 0.723
WC (cm) 86.54 ± 11.91 87.08 ± 10.87 87.78 ± 9.47 0.712 78.84 ± 9.71 78.08 ± 9.50 79.40 ± 9.01 0.534
WHR 0.87 ± 0.09 0.88 ± 0.08 0.88 ± 0.07 0.942 0.83 ± 0.10 0.82 ± 0.07 0.82 ± 0.07 0.399
IgE (IU/mL) 276.80 ± 645.41 229.82 ± 454.97 331.63 ± 768.03 0.613 95.65 ± 155.72 150.11 ± 346.92 139.44 ± 351.86 0.511
YKL-40 (ng/mL) 133.08 ± 128.56 99.16 ± 89.75 90.66 ± 109.85 < 0.0001a 105.15 ± 103.82 98.89 ± 108.91 63.403 ± 57.64 0.009a
FEV1%, pred 83.20 ± 20.89 80.96 ± 22.16 77.41 ± 21.05 0.116 92.81 ± 18.37 92.91 ± 14.58 88.30 ± 16.71 0.127
FVC%, pred 86.79 ± 20.83 85.09 ± 21.67 84.44 ± 21.79 0.562 98.69 ± 18.26 96.42 ± 16.31 97.18 ± 16.48 0.463
  1. a P value was presented by testing the total serum IgE and YKL-40 levels after log-transformation to follow normal distribution. (ANOVA and Bonferroni).