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Table 2 Summary of meta-analysis results

From: Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis

 

Dominant model

Recessive model

Allelic model

 

n

OR (95% CI)

P-value

Phet

I2

n

OR (95% CI)

P-value

Phet

I2

n

OR (95% CI)

P-value

Phet

I2

IL1A-889C/T

               

Total (sepsis)

2

1.49 (0.95-2.33)

0.08

0.65

0%

2

2.06 (0.75-5.67)

0.16

0.56

0%

2

1.47 (1.01-2.13)

0.04

0.98

0%

Ethnicity

               

Asian

1

1.41 (0.85-2.34)

0.19

  

1

2.65 (0.70-10.0)

0.15

  

1

1.47 (0.94-2.30)

0.09

  

Others

1

1.81 (0.69-4.74)

0.23

  

1

1.44 (0.30-6.94)

0.65

  

1

1.46 (0.74-2.87)

0.28

  

IL1B-511G/A

               

Total (sepsis)

7

0.81 (0.53-1.24)

0.33

<0.01

68%

6

0.89 (0.53-1.50)

0.66

<0.01

67%

6

0.82 (0.60-1.11)

0.20

<0.01

69%

Ethnicity

               

Asian

4

0.85 (0.39-1.87)

0.69

<0.01

81%

3

0.67 (0.29-1.55)

0.35

0.02

73%

3

0.74 (0.38-1.34)

0.29

<0.01

84%

Caucasian

1

0.86 (0.60-1.23)

0.40

  

1

0.68 (0.41-1.13)

0.14

  

1

0.84 (0.65-1.08)

0.18

  

Others

2

0.63 (0.24-1.66)

0.35

0.09

66%

2

1.73 (0.95-3.14)

0.07

0.76

0%

2

0.98 (0.58-1.65)

0.93

0.18

44%

Quality score

               

≥7

6

0.72 (0.48-1.9)

0.12

0.02

64%

6

0.89 (0.53-1.50)

0.66

<0.01

67%

6

0.82 (0.60-1.11)

0.20

<0.01

69%

<7

1

2.06 (0.94-4.55)

0.07

            

IL1B-31C/T

               

Total (high quality)

4

1.29 (0.54-3.06)

0.57

<0.01

86%

4

1.16 (0.86-1.56)

0.34

0.69

0%

4

1.18 (0.78-1.77)

0.43

<0.01

78%

Ethnicity

               

Asian

2

2.19 (0.70-6.90)

0.18

<0.01

89%

2

1.33 (0.84-2.09)

0.22

0.69

0%

2

1.53 (0.91-2.57)

0.11

0.04

77%

Caucasian

2

0.73 (0.33-1.61)

0.43

0.15

52%

2

1.04 (0.70-1.56)

0.85

0.40

0%

2

0.90 (0.57-1.43)

0.65

0.14

55%

Sepsis severity

               

Sepsis

3

1.75 (0.74-4.11)

0.20

<0.01

84%

3

1.24 (0.89-1.72)

0.20

0.85

0%

3

1.37 (0.93-2.00)

0.11

0.03

72%

Severe sepsis

1

0.47 (0.20-1.10)

0.08

  

1

0.78 (0.36-1.71)

0.54

  

1

0.68 (0.40-1.15)

0.15

  

Septic shock

               

IL1B + 3594C/T

               

Total

6

1.06 (0.86-1.31)

0.57

0.79

0%

5

0.59 (0.36-0.97)

0.04

0.81

0%

6

0.97 (0.81-1.15)

0.72

0.71

0%

Ethnicity

               

Asian

1

1.89 (0.60-5.96)

0.28

       

1

1.80 (0.60-5.41)

0.30

  

Caucasian

4

1.00 (0.80-1.25)

0.99

0.74

0%

4

0.57 (0.34-0.95)

0.03

0.74

0%

4

0.92 (0.76-1.11)

0.37

0.99

0%

Others

1

1.48 (0.78-2.81)

0.23

  

1

0.94 (0.19-4.81)

0.95

  

1

1.34 (0.77-2.33)

0.31

  

Sepsis severity

               

Sepsis

4

1.04 (0.83-1.30)

0.75

0.71

0%

4

0.55 (0.31-0.97)

0.04

0.73

0%

4

0.95 (0.78-1.15)

0.59

0.64

0%

Severe sepsis

1

1.07 (0.61-1.87)

0.82

  

1

0.75 (0.28-2.01)

0.56

  

1

0.98 (0.62-1.54)

0.93

  

Septic shock

1

1.89 (0.60-5.96)

0.28

       

1

1.80 (0.60-5.41)

0.30

  

Quality score

               

≥7

3

1.08 (0.82-1.42)

0.57

0.55

0%

3

0.63 (0.34-1.14)

0.13

0.71

0%

3

0.98 (0.78-1.23)

0.89

0.47

0%

<7

3

1.04 (0.75-1.43)

0.83

0.56

0%

3

0.53 (0.23-1.25)

0.15

0.37

0%

3

0.95 (0.72-1.24)

0.70

0.49

0%

IL1RN VNTR L/2

               

Total

9

1.39 (0.97-1.98)

0.07

0.01

59%

8

1.67 (0.93-3.02)

0.09

0.04

54%

8

1.40 (1.01-1.95)

0.04

<0.01

72%

Ethnicity

               

Asian

3

1.55 (0.89-2.68)

0.12

0.58

0%

1

2.51 (0.62-10.21)

0.20

  

2

1.69 (1.01-2.84)

0.05

0.64

0%

Caucasian

4

1.16 (0.72-1.88)

0.54

<0.01

75%

4

1.39 (0.66-2.92)

0.38

0.02

71%

4

1.17 (0.77-1.78)

0.45

<0.01

82%

Others

2

2.68 (0.84-8.50)

0.09

0.12

58%

2

3.17 (0.40-25.32)

0.28

0.15

52%

2

2.27 (0.78-6.58)

0.13

0.05

73%

Sepsis severity

               

Sepsis

5

1.26 (0.95-1.67)

0.11

0.69

0%

4

1.85 (1.12-3.04)

0.02

0.82

0%

4

1.31 (1.05-1.64)

0.02

0.70

0%

Severe sepsis

2

1.67 (1.03-2.71)

0.04

0.18

44%

2

2.16 (1.25-3.72)

0.01

0.77

0%

2

1.60 (1.18-2.17)

<0.01

0.25

24%

Septic shock

1

5.11 (1.59-16.46)

0.01

  

1

10.00 (1.08-92.49)

0.04

  

1

4.00 (1.72-9.31)

<0.01

  

Quality score

               

≥7

7

1.53 (0.95-2.47)

0.08

<0.01

67%

7

1.62 (0.72-3.65)

0.24

0.02

61%

7

1.46 (0.96-2.21)

0.08

<0.01

75%

<7

2

1.11 (0.79-1.55)

0.55

0.84

0%

1

1.83 (1.04-3.20)

0.03

  

1

1.22 (0.93-1.60)

0.14

  
  1. Random effects model is used whether or not heterogeneity exists; others contain African-American, Hispanic, and Jews/Arabs; n: the number of studies involved. OR: odds ratio; CI: confidence interval; P-value: P value of pooled OR; Phet: P of heterogeneity; Statistically significant results (P < 0.05) are highlighted in bold.