From: Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis
 | Dominant model | Recessive model | Allelic model | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | n | OR (95% CI) | P-value | Phet | I2 | n | OR (95% CI) | P-value | Phet | I2 | n | OR (95% CI) | P-value | Phet | I2 |
IL1A-889C/T | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Total (sepsis) | 2 | 1.49 (0.95-2.33) | 0.08 | 0.65 | 0% | 2 | 2.06 (0.75-5.67) | 0.16 | 0.56 | 0% | 2 | 1.47 (1.01-2.13) | 0.04 | 0.98 | 0% |
Ethnicity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Asian | 1 | 1.41 (0.85-2.34) | 0.19 | Â | Â | 1 | 2.65 (0.70-10.0) | 0.15 | Â | Â | 1 | 1.47 (0.94-2.30) | 0.09 | Â | Â |
Others | 1 | 1.81 (0.69-4.74) | 0.23 | Â | Â | 1 | 1.44 (0.30-6.94) | 0.65 | Â | Â | 1 | 1.46 (0.74-2.87) | 0.28 | Â | Â |
IL1B-511G/A | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Total (sepsis) | 7 | 0.81 (0.53-1.24) | 0.33 | <0.01 | 68% | 6 | 0.89 (0.53-1.50) | 0.66 | <0.01 | 67% | 6 | 0.82 (0.60-1.11) | 0.20 | <0.01 | 69% |
Ethnicity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Asian | 4 | 0.85 (0.39-1.87) | 0.69 | <0.01 | 81% | 3 | 0.67 (0.29-1.55) | 0.35 | 0.02 | 73% | 3 | 0.74 (0.38-1.34) | 0.29 | <0.01 | 84% |
Caucasian | 1 | 0.86 (0.60-1.23) | 0.40 | Â | Â | 1 | 0.68 (0.41-1.13) | 0.14 | Â | Â | 1 | 0.84 (0.65-1.08) | 0.18 | Â | Â |
Others | 2 | 0.63 (0.24-1.66) | 0.35 | 0.09 | 66% | 2 | 1.73 (0.95-3.14) | 0.07 | 0.76 | 0% | 2 | 0.98 (0.58-1.65) | 0.93 | 0.18 | 44% |
Quality score | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
≥7 | 6 | 0.72 (0.48-1.9) | 0.12 | 0.02 | 64% | 6 | 0.89 (0.53-1.50) | 0.66 | <0.01 | 67% | 6 | 0.82 (0.60-1.11) | 0.20 | <0.01 | 69% |
<7 | 1 | 2.06 (0.94-4.55) | 0.07 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
IL1B-31C/T | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Total (high quality) | 4 | 1.29 (0.54-3.06) | 0.57 | <0.01 | 86% | 4 | 1.16 (0.86-1.56) | 0.34 | 0.69 | 0% | 4 | 1.18 (0.78-1.77) | 0.43 | <0.01 | 78% |
Ethnicity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Asian | 2 | 2.19 (0.70-6.90) | 0.18 | <0.01 | 89% | 2 | 1.33 (0.84-2.09) | 0.22 | 0.69 | 0% | 2 | 1.53 (0.91-2.57) | 0.11 | 0.04 | 77% |
Caucasian | 2 | 0.73 (0.33-1.61) | 0.43 | 0.15 | 52% | 2 | 1.04 (0.70-1.56) | 0.85 | 0.40 | 0% | 2 | 0.90 (0.57-1.43) | 0.65 | 0.14 | 55% |
Sepsis severity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Sepsis | 3 | 1.75 (0.74-4.11) | 0.20 | <0.01 | 84% | 3 | 1.24 (0.89-1.72) | 0.20 | 0.85 | 0% | 3 | 1.37 (0.93-2.00) | 0.11 | 0.03 | 72% |
Severe sepsis | 1 | 0.47 (0.20-1.10) | 0.08 | Â | Â | 1 | 0.78 (0.36-1.71) | 0.54 | Â | Â | 1 | 0.68 (0.40-1.15) | 0.15 | Â | Â |
Septic shock | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
IL1B + 3594C/T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total | 6 | 1.06 (0.86-1.31) | 0.57 | 0.79 | 0% | 5 | 0.59 (0.36-0.97) | 0.04 | 0.81 | 0% | 6 | 0.97 (0.81-1.15) | 0.72 | 0.71 | 0% |
Ethnicity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Asian | 1 | 1.89 (0.60-5.96) | 0.28 | Â | Â | Â | Â | Â | Â | Â | 1 | 1.80 (0.60-5.41) | 0.30 | Â | Â |
Caucasian | 4 | 1.00 (0.80-1.25) | 0.99 | 0.74 | 0% | 4 | 0.57 (0.34-0.95) | 0.03 | 0.74 | 0% | 4 | 0.92 (0.76-1.11) | 0.37 | 0.99 | 0% |
Others | 1 | 1.48 (0.78-2.81) | 0.23 | Â | Â | 1 | 0.94 (0.19-4.81) | 0.95 | Â | Â | 1 | 1.34 (0.77-2.33) | 0.31 | Â | Â |
Sepsis severity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Sepsis | 4 | 1.04 (0.83-1.30) | 0.75 | 0.71 | 0% | 4 | 0.55 (0.31-0.97) | 0.04 | 0.73 | 0% | 4 | 0.95 (0.78-1.15) | 0.59 | 0.64 | 0% |
Severe sepsis | 1 | 1.07 (0.61-1.87) | 0.82 | Â | Â | 1 | 0.75 (0.28-2.01) | 0.56 | Â | Â | 1 | 0.98 (0.62-1.54) | 0.93 | Â | Â |
Septic shock | 1 | 1.89 (0.60-5.96) | 0.28 | Â | Â | Â | Â | Â | Â | Â | 1 | 1.80 (0.60-5.41) | 0.30 | Â | Â |
Quality score | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
≥7 | 3 | 1.08 (0.82-1.42) | 0.57 | 0.55 | 0% | 3 | 0.63 (0.34-1.14) | 0.13 | 0.71 | 0% | 3 | 0.98 (0.78-1.23) | 0.89 | 0.47 | 0% |
<7 | 3 | 1.04 (0.75-1.43) | 0.83 | 0.56 | 0% | 3 | 0.53 (0.23-1.25) | 0.15 | 0.37 | 0% | 3 | 0.95 (0.72-1.24) | 0.70 | 0.49 | 0% |
IL1RN VNTR L/2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Total | 9 | 1.39 (0.97-1.98) | 0.07 | 0.01 | 59% | 8 | 1.67 (0.93-3.02) | 0.09 | 0.04 | 54% | 8 | 1.40 (1.01-1.95) | 0.04 | <0.01 | 72% |
Ethnicity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Asian | 3 | 1.55 (0.89-2.68) | 0.12 | 0.58 | 0% | 1 | 2.51 (0.62-10.21) | 0.20 | Â | Â | 2 | 1.69 (1.01-2.84) | 0.05 | 0.64 | 0% |
Caucasian | 4 | 1.16 (0.72-1.88) | 0.54 | <0.01 | 75% | 4 | 1.39 (0.66-2.92) | 0.38 | 0.02 | 71% | 4 | 1.17 (0.77-1.78) | 0.45 | <0.01 | 82% |
Others | 2 | 2.68 (0.84-8.50) | 0.09 | 0.12 | 58% | 2 | 3.17 (0.40-25.32) | 0.28 | 0.15 | 52% | 2 | 2.27 (0.78-6.58) | 0.13 | 0.05 | 73% |
Sepsis severity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Sepsis | 5 | 1.26 (0.95-1.67) | 0.11 | 0.69 | 0% | 4 | 1.85 (1.12-3.04) | 0.02 | 0.82 | 0% | 4 | 1.31 (1.05-1.64) | 0.02 | 0.70 | 0% |
Severe sepsis | 2 | 1.67 (1.03-2.71) | 0.04 | 0.18 | 44% | 2 | 2.16 (1.25-3.72) | 0.01 | 0.77 | 0% | 2 | 1.60 (1.18-2.17) | <0.01 | 0.25 | 24% |
Septic shock | 1 | 5.11 (1.59-16.46) | 0.01 | Â | Â | 1 | 10.00 (1.08-92.49) | 0.04 | Â | Â | 1 | 4.00 (1.72-9.31) | <0.01 | Â | Â |
Quality score | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
≥7 | 7 | 1.53 (0.95-2.47) | 0.08 | <0.01 | 67% | 7 | 1.62 (0.72-3.65) | 0.24 | 0.02 | 61% | 7 | 1.46 (0.96-2.21) | 0.08 | <0.01 | 75% |
<7 | 2 | 1.11 (0.79-1.55) | 0.55 | 0.84 | 0% | 1 | 1.83 (1.04-3.20) | 0.03 | Â | Â | 1 | 1.22 (0.93-1.60) | 0.14 | Â | Â |