From: Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis
Author/Year | Country | Ethnicity | Sepsis severity | Sources of control | Genotyping method | Quality score | Case/control | Case | Control | PHWE | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | AB | BB | AA | AB | BB | Â | ||||||||
IL1α-889C/T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Davis 2010 | America | Hispanic | Sepsis | Community | TaqMan | 7 | 28/52 | 9 | 16 | 3 | 24 | 24 | 4 | 0.55 |
Gu 2010 | China | Asian | Sepsis | Hospital (trauma) | Probes | 8 | 165/141 | 114 | 42 | 9 | 107 | 31 | 3 | 0.67 |
IL-1B-511G/A | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Johnson-1 2012 | America | Caucasian | Sepsis | Hospital (noninfected) | Mass-array | 9 | 245/263 | 103 | 114 | 28 | 101 | 120 | 42 | 0.53 |
Johnson-2 2012 | America | African-American | Sepsis | Hospital (noninfected) | Mass-array | 9 | 93/88 | 28 | 36 | 29 | 26 | 43 | 19 | 0.88 |
Wan 2012 | China | Asian | Sepsis | Hospital (transplanted) | PCR-RFLP | 7 | 21/60 | 11 | 6 | 4 | 12 | 30 | 18 | 0.94 |
Shimada 2011 | Japan | Asian | Sepsis | Hospital (critical ill) | Probes | 7 | 123/101 | 33 | 60 | 30 | 35 | 46 | 20 | 0.49 |
Davis 2010 | America | Hispanic | Sepsis | Community | TaqMan | 7 | 28/53 | 17 | 6 | 5 | 19 | 29 | 5 | 0.20 |
Gu 2010 | China | Asian | Sepsis | Hospital (trauma) | Probes | 8 | 167/140 | 57 | 83 | 27 | 34 | 61 | 45 | 0.15 |
Watanabe 2005 | Japan | Asian | Sepsis | Hospital (SIRS) | Probes | 6 | 68/45 | 19 | Â | 49a | 20 | Â | 25a | 0.86 |
IL-1B-31C/T | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Shimada 2011 | Japan | Asian | Sepsis | Hospital (critical ill) | Probes | 8 | 122/101 | 36 | 58 | 28 | 34 | 47 | 20 | 0.61 |
Emonts 2010 | Netherlands | Caucasian | Sepsis | Community | SNaPshot | 7 | 84/456 | 10 | 37 | 37 | 57 | 214 | 185 | 0.69 |
Gu 2010 | China | Asian | Sepsis | Hospital (trauma) | Probes | 8 | 163/144 | 29 | 106 | 28 | 66 | 60 | 18 | 0.45 |
Barber 2004 | America | Caucasian | SS | Hospital (burn) | Pyro | 8 | 36/123 | 11 | 13 | 12 | 21 | 54 | 48 | 0.39 |
IL-1B + 3594C/T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Johnson-1 2012 | America | Caucasian | Sepsis | Hospital (noninfected) | Mass-array | 9 | 245/263 | 148 | 89 | 8 | 158 | 88 | 17 | 0.32 |
Johnson-2 2012 | America | African-American | Sepsis | Hospital (noninfected) | Mass-array | 9 | 93/88 | 61 | 29 | 3 | 65 | 20 | 3 | 0.36 |
Zhang 2005 | China | Asian | SSH | Hospital (ASP) | PCR-RFLP | 6 | 33/76 | 27 | 6 | 0 | 68 | 8 | 0 | 0.63 |
Balding 2003 | Ireland | Caucasian | Sepsis | Community | PCR-RFLP | 6 | 183/389 | 113 | 65 | 5 | 240 | 125 | 24 | 0.16 |
Treszl 2003 | Hungary | Caucasian | Sepsis | Hospital (VLBW) | PCR-RFLP | 6 | 33/70 | 20 | 11 | 2 | 41 | 25 | 4 | 0.94 |
Fang 1999 | Germany | Caucasian | SS | Community | PCR | 7 | 93/112 | 55 | 31 | 7 | 68 | 33 | 11 | 0.03 |
IL-1RN VNTR L/2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Zapata-Tarres 2013 | Mexico | Hispanic | SSH | Hospital (ALL) | PCR | 8 | 22/35 | 6 | 11 | 5 | 23 | 11 | 1 | 0.82 |
Wan 2012 | China | Asian | Sepsis | Hospital (transplanted) | PCR-RFLP | 7 | 21/60 | 17 | 4 | 0 | 51 | 9 | 0 | 0.53 |
Davis 2010 | America | Hispanic | Sepsis | Community | TaqMan | 7 | 28/50 | 12 | 14 | 2 | 27 | 20 | 3 | 0.78 |
Garcia-Segarra 2007 | Spain | Caucasian | SS and SSH | Community | PCR | 7 | 114/80 | 59 | 52 | 3 | 30 | 41 | 9 | 0.37 |
Watanabe 2005 | Japan | Asian | Sepsis | Hospital (SIRS) | PCR | 6 | 68/45 | 59 | Â | 9a | 39 | Â | 6a | 0.54 |
Bessler 2004 | Israel | Jews/Arabs | Sepsis | Community | PCR | 7 | 34/61 | 18 | 10 | 6 | 33 | 16 | 12 | 0.002 |
Balding 2003 | Ireland | Caucasian | Sepsis | Community | PCR-RFLP | 6 | 183/389 | 88 | 70 | 25 | 198 | 160 | 31 | 0.87 |
Arnalich 2002 | Spain | Caucasian | SS | Hospital (CAP) | PCR | 8 | 78/186 | 32 | 33 | 13 | 88 | 81 | 17 | 0.79 |
Ma 2002 | China | Asian | Sepsis | Community | PCR | 7 | 60/60 | 26 | 27 | 7 | 36 | 21 | 3 | 0.98 |
Fang 1999 | Germany | Caucasian | SS | Community | PCR | 7 | 93/261 | 37 | 43 | 13 | 152 | 92 | 17 | 0.54 |