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Table 1 Characteristics of studies included in the meta-analysis

From: Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis

Author/Year

Country

Ethnicity

Sepsis severity

Sources of control

Genotyping method

Quality score

Case/control

Case

Control

PHWE

AA

AB

BB

AA

AB

BB

 

IL1α-889C/T

              

Davis 2010

America

Hispanic

Sepsis

Community

TaqMan

7

28/52

9

16

3

24

24

4

0.55

Gu 2010

China

Asian

Sepsis

Hospital (trauma)

Probes

8

165/141

114

42

9

107

31

3

0.67

IL-1B-511G/A

              

Johnson-1 2012

America

Caucasian

Sepsis

Hospital (noninfected)

Mass-array

9

245/263

103

114

28

101

120

42

0.53

Johnson-2 2012

America

African-American

Sepsis

Hospital (noninfected)

Mass-array

9

93/88

28

36

29

26

43

19

0.88

Wan 2012

China

Asian

Sepsis

Hospital (transplanted)

PCR-RFLP

7

21/60

11

6

4

12

30

18

0.94

Shimada 2011

Japan

Asian

Sepsis

Hospital (critical ill)

Probes

7

123/101

33

60

30

35

46

20

0.49

Davis 2010

America

Hispanic

Sepsis

Community

TaqMan

7

28/53

17

6

5

19

29

5

0.20

Gu 2010

China

Asian

Sepsis

Hospital (trauma)

Probes

8

167/140

57

83

27

34

61

45

0.15

Watanabe 2005

Japan

Asian

Sepsis

Hospital (SIRS)

Probes

6

68/45

19

 

49a

20

 

25a

0.86

IL-1B-31C/T

              

Shimada 2011

Japan

Asian

Sepsis

Hospital (critical ill)

Probes

8

122/101

36

58

28

34

47

20

0.61

Emonts 2010

Netherlands

Caucasian

Sepsis

Community

SNaPshot

7

84/456

10

37

37

57

214

185

0.69

Gu 2010

China

Asian

Sepsis

Hospital (trauma)

Probes

8

163/144

29

106

28

66

60

18

0.45

Barber 2004

America

Caucasian

SS

Hospital (burn)

Pyro

8

36/123

11

13

12

21

54

48

0.39

IL-1B + 3594C/T

              

Johnson-1 2012

America

Caucasian

Sepsis

Hospital (noninfected)

Mass-array

9

245/263

148

89

8

158

88

17

0.32

Johnson-2 2012

America

African-American

Sepsis

Hospital (noninfected)

Mass-array

9

93/88

61

29

3

65

20

3

0.36

Zhang 2005

China

Asian

SSH

Hospital (ASP)

PCR-RFLP

6

33/76

27

6

0

68

8

0

0.63

Balding 2003

Ireland

Caucasian

Sepsis

Community

PCR-RFLP

6

183/389

113

65

5

240

125

24

0.16

Treszl 2003

Hungary

Caucasian

Sepsis

Hospital (VLBW)

PCR-RFLP

6

33/70

20

11

2

41

25

4

0.94

Fang 1999

Germany

Caucasian

SS

Community

PCR

7

93/112

55

31

7

68

33

11

0.03

IL-1RN VNTR L/2

              

Zapata-Tarres 2013

Mexico

Hispanic

SSH

Hospital (ALL)

PCR

8

22/35

6

11

5

23

11

1

0.82

Wan 2012

China

Asian

Sepsis

Hospital (transplanted)

PCR-RFLP

7

21/60

17

4

0

51

9

0

0.53

Davis 2010

America

Hispanic

Sepsis

Community

TaqMan

7

28/50

12

14

2

27

20

3

0.78

Garcia-Segarra 2007

Spain

Caucasian

SS and SSH

Community

PCR

7

114/80

59

52

3

30

41

9

0.37

Watanabe 2005

Japan

Asian

Sepsis

Hospital (SIRS)

PCR

6

68/45

59

 

9a

39

 

6a

0.54

Bessler 2004

Israel

Jews/Arabs

Sepsis

Community

PCR

7

34/61

18

10

6

33

16

12

0.002

Balding 2003

Ireland

Caucasian

Sepsis

Community

PCR-RFLP

6

183/389

88

70

25

198

160

31

0.87

Arnalich 2002

Spain

Caucasian

SS

Hospital (CAP)

PCR

8

78/186

32

33

13

88

81

17

0.79

Ma 2002

China

Asian

Sepsis

Community

PCR

7

60/60

26

27

7

36

21

3

0.98

Fang 1999

Germany

Caucasian

SS

Community

PCR

7

93/261

37

43

13

152

92

17

0.54

  1. SS: severe sepsis; SSH: septic shock; SIRS: systemic inflammatory response syndrome; ASP: acute severe pancreatitis; VLBW: very-low-birth-weight infants; ALL: acute lymphoblastic leukemia; CAP: community-acquired pneumonia; L signifies any long allele embracing allele 1, 3, 4, or 5; arepresents the number of AB + BB genotype (A represents the major allele, B represents the minor allele); PHWE < 0.05 is as a significant deviation from HWE.