Haplotype analysis of family pedigree and ultrasonic cardiogram (UCG) study of proband A. (A) All sampled subjects in the pedigree are identified by their Roman numerals below the symbol. Arabic numerals denote each individual in a generation. Open symbols = unaffected; filled symbols = affected; symbols with a diagonal line = deceased subjects; squares = male; circles = female; arrows = the probands; Haplotype analysis is shown for chromosome X using 11 markers. The black bar indicates the haplotype assumed to carry the disease allele. The bars with black and white haplotypes indicate the existence of recombination event. The minimal in-linkage interval is 6.2 Mb of genomic DNA, 20.9 cM in size between DXS8091 and DXS1073 on chromosome Xq28. (B) Ultrasonic cardiogram study of proband A shows chamber enlargement. LA = left atrium; LV = left ventricle; RA = right atrium; RV = right ventricle.