Table 3 Frequency of CYP3A4 and CYP3A5 polymorphisms in 20 HIV-infected patients
Genotype/20 pts | |||
|---|---|---|---|
Gene | Polymorphism | wt ( n. pts) | m ( n. pts) |
CYP3A4 | |||
CYP3A4*1B; 816 A > G 5′-flanking region | 17/20 | 3 | |
CYP3A4*2; 15831 T < C exon 7 | 20 | ||
CYP3A4*4; 13989 A > G exon 5 | 20 | ||
CYP3A4*5; 15820 C > G exon 7 | 20 | ||
CYP3A4*6; 17775 insA exon 9 | 20 | ||
CYP3A4*8; 14026 G > A exon 5 | 20 | ||
CYP3A4*11; 21973 C > T exon 11 | 20 | ||
CYP3A4*12; 22002 C > T exon 11 | 20 | ||
CYP3A4*13; 22132 C > T exon 11 | 20 | ||
CYP3A4*16; 15721 C > G exon 7 | 20 | ||
CYP3A4*17; 15733 T > C exon 7 | 20 | ||
CYP3A4*18; 20178 T > C exon 10 | 20 | ||
CYP3A5 | |||
CYP3A5*3; 12083 G > A intron 3 | 17/20 | 3 | |
CYP3A5*5; 18049 T > C intron 5 | 20 | ||
CYP3A5*6; 19787 G > A exon 7 | 20 | ||
CYP3A5*8; 8801 C > T exon 2 | 20 | ||
CYP3A5*9; 24483 G > A exon 10 | 20 | ||
CYP3A5*10; 34850 T > C exon 12 | 20 | ||