Figure 3

Magnetic resonance image of the proband. Sagittal SE T1-weighted cervical MRI (A, B) shows cerebrospinal fluid (CSF)-filled cavity (*) in the middle of the central cervical and thoracic spinal cord (SC), with multiple caudal septations. These non-neoplastic septated (white arrows) paracentral fluid containing cavitations are referred to as hydrosyringomyelia. Sagittal SE T1-weighted brain MRI (C) with the basion-opisthion line (BOL) shown in white. Note crowded foramen magnum and the low-lying pointed tonsil with distance from BOL >5 mm (black arrow), consistent with Chiari malformation 1. Axial MERGE T2*-weighted cervical MRI (D) shows a well-demarcated CSF cavity (*) in the middle central and left paracentral SC. VB, vertebral body; NF, neural foramina; SP, spinous process.