Skip to main content

Table 2 Genotype distributions of single nucleotide polymorphisms in SFTPD gene – patients with IIPs vs HS –

From: Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPDgene polymorphisms

 

German

Japanese

rs721917

Total

C/C

T/C

T/T

HWE

Total

C/C

T/C

T/T

HWE

 Patients with IIPs

102

25

47

30

0.862

63

19

30

14

0.973

(24.5%)

(46.1%)

(29.4%)

(30.2%)

(47.6%)

(22.2%)

 Healthy subjects

37

9

11

17

0.266

275

95

136

44

0.960

(24.3%)

(29.7%)

(46.0%)

(34.5%)

(49.5%)

(16.0%)

 Chi-square test

 

p = 0.140

  

p = 0.476

 

rs1998374

Total

C/C

T/C

T/T

HWE

Total

C/C

T/C

T/T

HWE

 Patients with IIPs

102

3

18

81

0.655

63

6

35

22

0.561

(2.9%)

(17.7%)

(79.4%)

(9.5%)

(55.6%)

(34.9%)

 Healthy subjects

37

0

5

32

0.913

275

57

125

93

0.679

(0.0%)

(13.5%)

(86.5%)

(20.7%)

(45.5%)

(33.8%)

 Chi-square test

 

p = 0.464

  

p = 0.102

 

rs2243639

Total

C/C

T/C

T/T

HWE

Total

C/C

T/C

T/T

HWE

 Patients with IIPs

102

43

45

14

0.960

63

28

28

7

1.000

(42.2%)

(44.1%)

(13.7%)

(44.4%)

(44.4%)

(11.1%)

 Healthy subjects

37

13

15

9

0.741

275

140

113

22

0.996

(35.1%)

(40.6%)

(24.3%)

(50.9%)

(41.1%)

(8.0%)

 Chi-square test

 

p = 0.324

  

p = 0.563

 

rs3088308

Total

A/A

A/T

T/T

HWE

Total

A/A

A/T

T/T

HWE

 Patients with IIPs

102

86

16

0

0.711

63

59

4

0

0.968

(84.3%)

(15.7%)

(0.0%)

(93.7%)

(6.3%)

(0.0%)

 Healthy subjects

37

32

5

0

0.913

275

265

10

0

0.955

(86.5%)

(13.5%)

(0.0%)

(96.4%)

(3.6%)

(0.0%)

 Chi-square test

 

p = 0.752

  

p = 0.330

 
  1. IIPs, Idiopathic interstitial pneumonias; HWE, Hardy-Weinberg equilibrium.
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us