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Table 5 Different gene significant downregulated GO

From: Expression analysis of genes and pathways associated with liver metastases of the uveal melanoma

GO item

Fold enrichment

P value

Calcium-dependent cell-cell adhesion

9.49

3.90 × 10-2

Response to acid

9.09

4.22 × 10-2

Embryonic skeletal system development

5.67

4.04 × 10-3

Response to vitamin

5.51

1.26 × 10-2

Regulation of cell shape

5.39

3.75 × 10-2

Regulation of Rho protein signal transduction

5.14

2.36 × 10-3

Pigmentation

4.93

4.68 × 10-2

Cartilage development

4.91

1.85 × 10-2

Skeletal system morphogenesis

3.90

1.88 × 10-2

Regulation of cell morphogenesis

3.89

9.22 × 10-3

Translational elongation

3.60

4.97 × 10-2

Muscle tissue development

3.49

2.85 × 10-2

Homophilic cell adhesion

3.33

3.40 × 10-2

Regulation of neuron differentiation

3.28

3.59 × 10-2

Embryonic organ morphogenesis

3.28

3.59 × 10-2

Regulation of cell development

3.19

7.23 × 10-3

Regulation of Ras protein signal transduction

3.12

8.25 × 10-3

Muscle organ development

3.10

8.54 × 10-3

Regulation of neurogenesis

3.07

2.66 × 10-2

Response to drug

3.03

9.75 × 10-3

Embryonic organ development

2.96

3.09 × 10-2

Regulation of small GTPase mediated signal transduction

2.89

7.88 × 10-3

Skeletal system development

2.74

4.38 × 10-3

Heart development

2.71

2.85 × 10-2

Regulation of nervous system development

2.65

4.85 × 10-2

Cell-cell adhesion

2.64

1.37 × 10-2

Negative regulation of cell proliferation

2.62

4.07 × 10-3

Cell adhesion

2.60

2.99 × 10-5

Biological adhesion

2.59

3.06 × 10-5

Actin cytoskeleton organization

2.57

3.59 × 10-2

Actin filament-based process

2.41

4.79 × 10-2

Chordate embryonic development

2.20

3.87 × 10-2

Embryonic development ending in birth or egg hatching

2.18

4.03 × 10-2

Cytoskeleton organization

2.17

1.68 × 10-2

Regulation of cell proliferation

2.03

2.54 × 10-3

Response to organic substance

1.71

3.85 × 10-2