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Table 2 rs4606 and risk of hypertension (SBP ≥ 140 mmHg/DBP ≥ 90 mmHg and/or taking antihypertensive drugs) according to obstetric history

From: Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: data from the Norwegian HUNT2 study

 

Unadjusted

Age-adjusted

Age and BMI-adjusted

Obstetric history group

OR (95% CI)

P

Number included in analysis (n)

OR (95% CI)

P

Number included in analysis (n)

OR (95% CI)

P

Number included in analysis (n)

Preeclampsia + control

CG: 1.07 (0.90-1.27)

0.451

2945

CG: 1.10 (0.91-1.33)

0.321

2945

CG: 1.12 (0.92-1.36)

0.254

2937

GG: 1.23 (0.90-1.67)

0.193

GG: 1.41 (1.01-1.97)

0.047*

GG: 1.49 (1.05-2.11)

0.027*

Control

CG: 0.998 (0.80-1.25)

0.989

2012

CG: 1.07 (0.84-1.36)

0.604

2012

CG: 1.07 (0.83-1.38)

0.595

2007

GG: 1.02 (0.68-1.54)

0.923

GG: 1.23 (0.78-1.92)

0.369

GG: 1.28 (0.80-2.04)

0.303

Preeclampsia

CG: 1.07 (0.81-1.41)

0.653

933

CG: 0.98 (0.72-1.33)

0.897

933

CG: 1.03 (0.76-1.41)

0.838

930

GG: 1.53 (0.93-2.52)

0.094

GG: 1.61 (0.93-2.80)

0.091

GG: 1.76 (1.00-3.11)

0.052

Early-onset preeclampsia

CG: 3.30 (0.87-12.5)

0.079

50

CG: 4.50 (0.93-21.9)

0.062

50

CG: 7.90 (1.30-48.2)

0.025*

50

CG/GG: 3.38 (0.90-12.6)

0.070

CG/GG: 4.68 (0.98-22.3)

0.053

CG/GG: 7.96 (1.33-47.8)

0.023*

Later onset preeclampsia

CG: 1.01 (0.76-1.34)

0.946

883

CG: 0.913 (0.67-1.25)

0.570

883

CG: 0.95 (0.69-1.31)

0.761

880

GG: 1.47 (0.88-2.43)

0.139

GG: 1.53 (0.87-2.68)

0.137

GG: 1.68 (0.94-2.98)

0.079

Recurrent preeclampsia

CG: 1.98 (0.98-4.01)

0.058

158

CG: 1.73 (0.84-3.58)

0.139

158

CG: 1.66 (0.79-3.49)

0.183

158

CG/GG: 2.04 (1.03-4.03)ǂ

0.040*

CG/GG: 1.78 (0.89-3.59)ǂ

0.106

CG/GG: 1.81 (0.88-3.71)ǂ

0.105

Non-recurrent preeclampsia

CG: 0.95 (0.70-1.29)

0.747

775

CG: 0.871 (0.62-1.23)

0.428

775

CG: 0.94 (0.66-1.33)

0.710

772

GG: 1.43 (0.82-2.49)

0.212

GG: 1.58 (0.84-2.98)

0.159

GG: 1.62 (0.85-3.12)

0.145

  1. *Statistically significant P < 0.05. SBP: Systolic blood pressure. DBP: Diastolic blood pressure. Reference genotype: CC. Merging of CG + GG genotype (n = 28) due to low numbers in GG genotype group (n = 2).
  2. ǂMerging of CG + GG genotype (n = 91) due to low numbers in GG genotype group (n = 15). Non-recurrent preeclampsia: primiparas and multiparas with only one preeclamptic pregnancy.