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Table 9 GCLC-3506A > G polymorphism in association with CF clinical variables as distributed by CFTR mutation

From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

Variable

Without taking CFTRmutation into account

No CFTRmutations identified

No CFTRmutations identified with PI

One identified CFTRmutation

One identified CFTRmutation with PI

Two identified CFTRmutations

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

Gendera

0.753

1

0.532

1

1

1

0.149

0.596

0.510

1

0.824

1

Agea

0.057

0.228

0.710

1

0.245

0.980

0.541

1

1

1

0.339

1

Onset of symptomsa

1

1

1

1

0.420

1

0.731

1

0.078

0.312

0.812

1

Onset of pulmonary diseasea

0.507

1

1

1

0.152

0.608

0.727

1

0.302

1

0.816

1

Onset of digestive diseasea

0.865

1

0.646

1

0.408

1

1

1

0.158

0.632

1

1

Diagnosisa

0.335

1

0.419

1

1

1

0.330

1

1

1

1

1

BMIa

1

1

1

1

0.281

1

0.704

1

0.709

1

0.785

1

Bhalla scoreb

0.35

1

0.830

1

0.468

1

0.169

0.676

0.833

1

0.495

1

Kanga scoreb

0.011

0.044

0.734

1

0.788

 

0.067

0.268

0.588

1

0.027

0.108

Shwachman-Kulczycki scoreb

0.091

0.364

0.725

1

0.223

0.892

0.034

0.136

0.545

1

0.159

0.636

Nasal polyposisa

0.688

1

0.251

1

0.555

1

0.692

1

1

1

0.083

0.332

Diabetes mellitusa

0.688

1

1

1

1

1

0.419

1

0.217

0.868

1

1

Osteoporosisa

0.133

0.532

1

1

0.068

0.272

0.25

1

0.630

1

0.335

 

Meconium ileus

1

1

1

1

0.304

1

1

1

0.417

1

1

1

Pancreatic insufficiencya

0.698

1

0.180

0.720

-

-

0.376

1

-

-

1

1

SpO2b

0.033

0.132

0.234

0.936

0.142

0.568

0.548

1

0.134

0.536

0.149

0.596

FVC(%)b

0.412

1

0.944

1

0.061

0.244

0.036

0.144

0.755

1

0.955

1

FEV1(%)b

0.166

0.664

0.877

1

0.094

0.376

0.030

0.120

0.381

1

0.577

1

FEV1/FVCb

0.054

0.216

0.912

1

0.403

1

0.050

0.200

0.247

0.988

0.111

 

FEF25–75%b

0.061

0.244

0.934

1

0.177

0.708

0.029

0.116

0.577

1

0.272

1

First P. aeruginosa a

0.350

1

0.453

1

0.433

1

0.716

1

0.015

0.060

0.799

1

P. aeruginosa mucoida

0.152

0.608

1

1

0.443

1

0.064

0.256

0.178

0.712

0.371

1

P. aeruginosa no mucoida

0.057

0.228

1

1

0.243

0.972

0.003

0.012

0.023

0.092

0.351

1

A. xylosoxidans a

0.187

0.748

0.066

 

0.044

0.176

0.565

1

1

1

0.343

1

S. aureus a

0.849

1

0.708

1

1

1

0.376

1

0.024

0.096

0.394

1

B. cepacia a

0.246

0.984

1

1

1

1

0.471

1

0.082

0.328

0.394

1

  1. aFisher’s exact test used for categorical variables; bStudent’s t-test used for numerical variables. P-values < 0.05 denote clinical association (bold).
  2. CFTR, Cystic fibrosis transmembrane regulator; GCLC, Glutamate cysteine ligase catalytic subunit; PI, Pancreatic insufficiency; BMI, Body mass index; SpO2, Hemoglobin oxygen saturation in the blood; FVC, Forced vital capacity; FEV1, Forced expiratory volume in the first second; FEF, Forced expiratory flow between 25 and 75% of vital capacity.