From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study
Variable | Without taking CFTRmutation into account | No CFTRmutations identified | No CFTRmutations identified with PI | One identified CFTRmutation | One identified CFTRmutation with PI | Two identified CFTRmutations | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | p-value | p-corrected | |
Gendera | 0.577 | 1 | 1 | 1 | 1 | 1 | 0.024 | 0.096 | 0.698 | 1 | 0.418 | 1 |
Agea | 0.348 | 1 | 1 | 1 | 0.667 | 1 | 1 | 1 | 1 | 1 | 0.249 | 0.996 |
Onset of symptomsa | 1 | 1 | 0.165 | 0.660 | 0.401 | 1 | 1 | 1 | 1 | 1 | 0.392 | 1 |
Onset of pulmonary diseasea | 0.162 | 0.648 | 1 | 1 | 1 | 1 | 0.409 | 1 | 0.685 | 1 | 0.168 | 0.672 |
Onset of digestive diseasea | 1 | 1 | 0.142 | 0.568 | 0.354 | 1 | 0.710 | 1 | 0.650 | 1 | 0.583 | 1 |
Diagnosisa | 1 | 1 | 1 | 1 | 0.405 | 1 | 0.715 | 1 | 0.412 | 1 | 0.764 | 1 |
BMIa | 1 | 1 | 0.414 | 1 | 0.559 | 1 | 0.331 | 1 | 1 | 1 | 1 | 1 |
Bhalla scoreb | 0.626 | 1 | 0.47 | 1 | 0.023 | 0.092 | 0.851 | 1 | 0.090 | 0.360 | 0.834 | 1 |
Kanga scoreb | 0.277 | 1 | 0.45 | 1 | 0.632 | 1 | 0.687 | 1 | 0.625 | 1 | 0.192 | 0.768 |
Shwachman-Kulczycki scoreb | 0.917 | 1 | 0.532 | 1 | 0.041 | 0.164 | 0.405 | 1 | 0.435 | 1 | 0.767 | 1 |
Nasal polyposisa | 0.811 | 1 | 0.66 | 1 | 0.555 | 1 | 0.332 | 1 | 0.577 | 1 | 0.066 | 0.264 |
Diabetes mellitusa | 0.811 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0.315 | 1 | 0.505 | 1 |
Osteoporosisa | 0.306 | 1 | 1 | 1 | 0.299 | 1 | 0.353 | 1 | 1 | 1 | 0.238 | 0.952 |
Meconium ileus | 0.792 | 1 | 1 | 1 | 0.576 | 1 | 0.651 | 1 | 0.147 | 0.588 | 0.727 | 1 |
Pancreatic insufficiencya | 0.063 | 0.252 | 0.267 | 1 | - | - | 0.328 | 1 | 1 | 1 | ||
SpO2b | 0.384 | 1 | 0.296 | 1 | 0.078 | 0.312 | 0.124 | 0.496 | 0.864 | 1 | 0.597 | 1 |
FVC(%)b | 0.822 | 1 | 0.828 | 1 | 0.127 | 0.508 | 0.922 | 1 | 0.506 | 1 | 0.597 | 1 |
FEV1(%)b | 0.598 | 1 | 0.310 | 1 | 0.160 | 0.640 | 0.983 | 1 | 0.510 | 1 | 0.820 | 1 |
FEV1/FVCb | 1 | 1 | 0.109 | 0.436 | 0.386 | 1 | 0.873 | 1 | 0.820 | 1 | 0.170 | 0.680 |
FEF25–75%b | 0.448 | 1 | 0.044 | 0.176 | 1 | 1 | 0.982 | 1 | 0.767 | 1 | 0.537 | 1 |
First P. aeruginosa a | 1 | 1 | 1 | 1 | 0.691 | 1 | 0.695 | 1 | 0.361 | 1 | 1 | 1 |
P. aeruginosa mucoida | 0.133 | 0.532 | 1 | 1 | 0.689 | 1 | 0.011 | 0.044 | 0.427 | 1 | 1 | 1 |
P. aeruginosa no mucoida | 1 | 1 | 1 | 1 | 1 | 1 | 0.266 | 1 | 0.680 | 1 | 0.391 | 1 |
A. xylosoxidans a | 0.534 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
S. aureus a | 0.261 | 1 | 0.093 | 0.372 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
B. cepacia a | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0.318 | 1 | 1 | 1 |