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Table 8 GCLC-129C > T polymorphism associated with CF clinical variables as distributed by CFTR mutation

From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

Variable

Without taking CFTRmutation into account

No CFTRmutations identified

No CFTRmutations identified with PI

One identified CFTRmutation

One identified CFTRmutation with PI

Two identified CFTRmutations

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

Gendera

0.577

1

1

1

1

1

0.024

0.096

0.698

1

0.418

1

Agea

0.348

1

1

1

0.667

1

1

1

1

1

0.249

0.996

Onset of symptomsa

1

1

0.165

0.660

0.401

1

1

1

1

1

0.392

1

Onset of pulmonary diseasea

0.162

0.648

1

1

1

1

0.409

1

0.685

1

0.168

0.672

Onset of digestive diseasea

1

1

0.142

0.568

0.354

1

0.710

1

0.650

1

0.583

1

Diagnosisa

1

1

1

1

0.405

1

0.715

1

0.412

1

0.764

1

BMIa

1

1

0.414

1

0.559

1

0.331

1

1

1

1

1

Bhalla scoreb

0.626

1

0.47

1

0.023

0.092

0.851

1

0.090

0.360

0.834

1

Kanga scoreb

0.277

1

0.45

1

0.632

1

0.687

1

0.625

1

0.192

0.768

Shwachman-Kulczycki scoreb

0.917

1

0.532

1

0.041

0.164

0.405

1

0.435

1

0.767

1

Nasal polyposisa

0.811

1

0.66

1

0.555

1

0.332

1

0.577

1

0.066

0.264

Diabetes mellitusa

0.811

1

1

1

1

1

1

1

0.315

1

0.505

1

Osteoporosisa

0.306

1

1

1

0.299

1

0.353

1

1

1

0.238

0.952

Meconium ileus

0.792

1

1

1

0.576

1

0.651

1

0.147

0.588

0.727

1

Pancreatic insufficiencya

0.063

0.252

0.267

1

-

-

0.328

1

  

1

1

SpO2b

0.384

1

0.296

1

0.078

0.312

0.124

0.496

0.864

1

0.597

1

FVC(%)b

0.822

1

0.828

1

0.127

0.508

0.922

1

0.506

1

0.597

1

FEV1(%)b

0.598

1

0.310

1

0.160

0.640

0.983

1

0.510

1

0.820

1

FEV1/FVCb

1

1

0.109

0.436

0.386

1

0.873

1

0.820

1

0.170

0.680

FEF25–75%b

0.448

1

0.044

0.176

1

1

0.982

1

0.767

1

0.537

1

First P. aeruginosa a

1

1

1

1

0.691

1

0.695

1

0.361

1

1

1

P. aeruginosa mucoida

0.133

0.532

1

1

0.689

1

0.011

0.044

0.427

1

1

1

P. aeruginosa no mucoida

1

1

1

1

1

1

0.266

1

0.680

1

0.391

1

A. xylosoxidans a

0.534

1

1

1

1

1

1

1

1

1

1

1

S. aureus a

0.261

1

0.093

0.372

1

1

1

1

1

1

1

1

B. cepacia a

1

1

1

1

1

1

1

1

0.318

1

1

1

  1. aFisher’s exact test used for categorical variables; bStudent’s t-test used for numerical variables. P-values < 0.05 denote clinical association (bold).
  2. CFTR, Cystic fibrosis transmembrane regulator; PI, Pancreatic insufficiency; GCLC, Glutamate cysteine ligase catalytic subunit; BMI, Body mass index; SpO2, Hemoglobin oxygen saturation in the blood; FVC, Forced vital capacity; FEV1, Forced expiratory volume in the first second; FEF, Forced expiratory flow between 25 and 75% of vital capacity.