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Table 14 GSTP1 + 313A > G polymorphism in association with CF clinical variables as distributed by CFTR mutation

From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

Variable

Without taking CFTRmutation into account

No CFTRmutations identified

No CFTRmutations identified with PI

One identified CFTRmutation

One identified CFTRmutation with PI

Two identified CFTRmutations

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

Gendera

0.550

1

0.396

1

1

1

0.267

1

0.763

1

0.184

0.736

Agea

0.011

0.044

0.750

1

0.500

1

0.051

0.204

1

1

0.058

0.232

Onset of symptomsa

0.876

1

0.473

1

0.720

1

1

1

0.531

1

1

1

Onset of pulmonary diseasea

0.754

1

0.729

1

0.252

1

0.757

1

0.757

1

1

1

Onset of digestive diseasea

0.516

1

1

1

0.462

1

0.761

1

1

1

1

1

Diagnosisa

0.644

1

0.694

1

0.185

0.740

0.561

1

0.763

1

0.441

1

BMIa

0.856

1

0.331

1

1

1

1

1

0.488

1

1

1

Bhalla scoreb

0.098

0.392

0.187

1

0.671

1

0.491

1

0.098

0.392

0.392

1

Kanga scoreb

0.716

1

0.867

1

0.604

1

0.407

1

0.416

1

0.300

1

Shwachman-Kulczycki scoreb

0.554

1

0.984

1

0.121

0.484

0.73

1

0.198

0.792

0.170

0.680

Nasal polyposisa

0.848

1

0.306

1

0.601

1

1

1

0.412

1

0.562

1

Diabetes mellitusa

0.336

1

1

1

1

1

0.703

1

1

1

0.582

1

Osteoporosisa

0.159

0.318

0.715

0.953

  

1

1

0.345

1

0.009

0.036

Meconium ileus

0.403

1

1

1

0.398

1

1

1

0.457

1

0.161

0.644

Pancreatic insufficiencya

0.581

1

0.393

1

0.187

0.748

0.703

1

-

-

0.578

1

SpO2b

0.967

1

0.839

1

0.230

0.920

0.156

0.624

0.157

0.628

0.346

1

FVC(%)b

0.441

1

0.407

1

0.279

1

0.849

1

0.315

1

0.626

1

FEV1(%)b

0.338

1

0.467

1

0.923

1

0.907

1

0.221

0.884

0.451

1

FEV1/FVCb

0.295

1

0.265

1

0.218

0.872

0.575

1

0.771

1

0.439

1

FEF25–75%b

0.146

0.584

0.498

1

0.261

1

0.505

1

0.379

1

0.291

1

First P. aeruginosa a

0.035

0.140

1

1

0.473

1

0.056

0.224

1

1

0.203

0.812

P. aeruginosa mucoida

0.289

1

0.331

1

0.505

1

0.782

1

0.760

1

0.653

1

P. aeruginosa no mucoida

1

1

0.548

1

1

1

0.776

1

0.760

1

0.482

1

A. xylosoxidans a

0.806

1

0.196

0.784

1

1

0.350

1

0.488

1

0.755

1

S. aureus a

0.721

1

0.507

1

1

1

0.743

1

0.185

0.740

0.565

1

B. cepacia a

0.667

1

0.196

0.784

1

1

0.703

1

0.698

1

0.404

1

  1. aFisher’s exact test used for categorical variables; bStudent’s t-test used for numerical variables. P-values < 0.05 denote clinical association (bold).
  2. CFTR, Cystic fibrosis transmembrane regulator; GSTP1, Glutathione S-transferase pi 1; PI, Pancreatic insufficiency; BMI, Body mass index; SpO2, Hemoglobin oxygen saturation in the blood; FVC, Forced vital capacity; FEV1, Forced expiratory volume in the first second; FEF, Forced expiratory flow between 25 and 75% of vital capacity.
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BMC Medical Genetics

ISSN: 1471-2350

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