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Table 12 GSTT1 deletion polymorphism in association with CF clinical variables as distributed by CFTR mutation

From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

Variable

Without taking CFTRmutation into account

No CFTRmutations identified

No CFTRmutations identified with PI

One identified CFTRmutation

One identified CFTRmutation with PI

Two identified CFTRmutations

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

Gendera

0.211

0.844

0.778

1

0.378

1

1

1

0.215

0.860

0.081

0.324

Agea

0.043

0.166

0.750

1

0.505

1

0.083

0.332

0.531

1

0.795

0.795

Onset of symptomsa

1

1

0.305

1

1

1

0.202

0.808

0.746

1

0.600

1

Onset of pulmonary diseasea

0.620

1

0.721

1

0.229

0.916

0.521

1

0.746

1

0.796

1

Onset of digestive diseasea

0.863

1

0.390

1

1

1

0.344

1

0.179

0.716

1

1

Diagnosisa

0.745

1

1

1

0.303

1

0.068

0.272

0.537

1

0.779

1

BMIa

0.447

1

0.747

1

0.103

0.412

0.295

1

0.728

1

0.537

1

Bhalla scoreb

0.485

1

0.824

1

0.134

0.536

0.322

1

0.634

1

0.185

0.740

Kanga scoreb

0.737

1

0.743

1

0.421

1

0.953

1

0.321

1

0.767

1

Shwachman-Kulczycki scoreb

0.734

1

0.984

1

0.013

0.052

0.653

1

0.925

1

0.393

1

Nasal polyposisa

0.313

1

1

1

1

1

0.062

0.248

0.685

1

1

1

Diabetes mellitusa

0.158

0.632

0.115

0.460

0.398

1

0.450

1

0.071

0.284

0.764

1

Osteoporosisa

1

1

1

1

0.085

0.340

1

1

0.230

0.920

0.718

1

Meconium ileus

0.276

1

0.077

0.308

0.658

1

1

1

0.445

1

0.335

1

Pancreatic insufficiencya

0.847

1

0.561

1

-

-

1

1

-

-

0.557

1

SaO2b

0.988

1

0.740

1

0.170

0.680

0.595

1

0.333

1

0.703

1

FVC(%)b

0.268

1

0.086

0.344

0.154

0.616

0.464

1

0.412

1

0.623

1

FEV1(%)b

0.310

1

0.167

0.668

0.029

0.116

0.564

1

0.597

1

0.636

1

FEV1/FVCb

0.404

1

0.288

1

0.017

0.068

0.692

1

0.676

1

0.424

1

FEF25–75%b

0.687

1

0.390

1

0.027

0.108

0.686

1

0.829

1

0.959

1

First P. aeruginosa a

0.472

1

1

1

0.724

1

0.320

1

0.713

1

0.085

0.340

P. aeruginosa mucoida

0.433

1

0.747

1

1

1

0.393

1

0.753

1

1

1

P. aeruginosa no mucoida

0.876

1

0.002

0.008

0.489

1

0.133

0.266

0.541

1

1

1

A. xylosoxidans a

0.437

1

1

1

0.338

1

0.623

1

0.151

0.604

0.295

1

S. aureus a

0.705

1

1

1

0.658

1

0.325

1

0.735

1

1

1

B. cepacia a

1

1

1

1

0.177

0.708

0.699

1

0.407

1

0.215

0.860

  1. aFisher’s exact test used for categorical variables; bStudent’s t-test used for numerical variables. P-values < 0.05 denote clinical association (bold).
  2. CFTR, Cystic fibrosis transmembrane regulator; GSTT1, Glutathione S-transferase theta 1; PI, Pancreatic insufficiency; BMI, Body mass index; SpO2, Hemoglobin oxygen saturation in the blood; FVC, Forced vital capacity; FEV1, Forced expiratory volume in the first second; FEF, Forced expiratory flow between 25 and 75% of vital capacity.
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BMC Medical Genetics

ISSN: 1471-2350

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