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Table 11 GSTM1 deletion polymorphism in association with CF clinical variables as distributed by CFTR mutation

From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

Variable

Without taking CFTRmutation into account

No CFTRmutations identified

No CFTRmutations identified with PI

One identified CFTRmutation

One identified CFTRmutation with PI

Two identified CFTRmutations

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

Gendera

0.171

0.684

0.764

1

0.075

0.300

0.267

1

0.537

1

0.110

0.440

Agea

1

1

0.498

1

0.736

1

0.579

1

1

1

1

1

Onset of symptomsa

0.268

1

0.459

1

0.721

1

1

1

1

1

0.629

1

Onset of pulmonary diseasea

0.424

1

0.068

0.272

1

1

1

1

0.742

1

0.639

1

Onset of digestive diseasea

0.409

1

0.665

1

1

1

1

1

0.008

0.032

0.635

1

Diagnosisa

1

1

0.059

0.236

0.729

1

0.149

0.596

1

1

1

 

BMIa

0.462

1

0.503

1

0.115

0.460

0.725

1

1

1

0.169

0.676

Bhalla scoreb

0.86

1

0.11

0.44

0.059

0.236

0.050

0.200

0.692

1

0.879

1

Kanga scoreb

0.982

1

0.693

1

0.367

1

0.822

1

0.480

1

0.784

1

Shwachman-Kulczycki scoreb

0.501

1

0.449

1

0.884

1

0.123

0.492

0.777

1

0.568

1

Nasal polyposisa

0.331

1

0.136

0.544

0.610

1

1

1

0.407

1

0.765

1

Diabetes mellitusa

0.560

1

1

1

1

1

0.703

1

1

1

0.169

0.676

Osteoporosisa

0.217

0.868

0.435

1

0.377

1

0.173

 

0.633

1

1

1

Meconium ileus

1

1

1

1

0.640

1

0.726

1

1

1

0.776

1

Pancreatic insufficiencya

1

1

0.765

1

-

-

1

1

-

-

1

1

SpO2b

0.187

0.748

0.012

0.048

0.500

1

0.780

1

0.652

1

0.645

1

FVC(%)b

0.990

1

0.741

1

0.020

0.08

0.538

1

0.307

1

0.967

1

FEV1(%)b

0.827

1

0.623

1

0.030

0.012

0.786

1

0.972

1

0.943

1

FEV1/FVCb

0.915

1

0.749

1

0.532

1

0.918

1

0.244

0.976

0.597

1

FEF25–75%b

0.853

1

0.718

1

0.197

0.788

0.819

1

0.255

1

0.847

1

First P. aeruginosa a

0.724

1

1

1

0.473

1

0.056

0.224

1

1

0.312

1

P. aeruginosa mucoida

0.092

0.368

0.729

1

0.289

1

1

1

0.541

1

0.107

0.428

P. aeruginosa no mucoida

0.879

1

0.754

1

0292

1

0.776

1

1

1

0.629

1

A. xylosoxidans a

0.619

1

0.537

1

1

1

0.35

1

0.511

1

0.52

1

S. aureus a

0.362

1

0.175

0.700

0.391

1

1

1

1

1

0.776

1

B. cepacia a

0.371

1

0.116

0.464

0.313

1

0.703

1

1

1

1

1

  1. aFisher’s exact test used for categorical variables; bStudent’s t-test used for numerical variables. P-values < 0.05 denote clinical association (bold).
  2. CFTR, Cystic fibrosis transmembrane regulator; GSTM1, Glutathione S-transferase mu 1; PI, Pancreatic insufficiency; BMI, Body mass index; SpO2, Hemoglobin oxygen saturation in the blood; FVC, Forced vital capacity; FEV1, Forced expiratory volume in the first second; FEF, Forced expiratory flow between 25 and 75% of vital capacity.
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BMC Medical Genetics

ISSN: 1471-2350

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