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Table 10 GCLC-129C > T and GCLC-3506A > G polymorphisms by haplotype in association with CF clinical variables as distributed by CFTR mutation

From: Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

Variable

Without taking CFTRmutation into account

No CFTRmutations identified

No CFTRmutations identified with PI

One identified CFTRmutation

One identified CFTRmutation with PI

Two identified CFTRmutations

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

p-value

p-corrected

Gendera

0.285

1

0.302

1

0.505

1

0.424

1

0.479

1

0.223

0.892

Agea

0.437

1

0.639

1

0.382

1

0.601

1

0.777

1

0.625

1

Onset of symptomsa

0.098

0.392

0.407

1

0.421

1

0.143

0.572

0.180

0.720

0.036

0.144

Onset of pulmonary diseasea

0.802

1

0.091

0.364

0.163

0.652

0.424

1

0.321

1

0.980

1

Onset of digestive diseasea

0.640

1

0.237

0.948

0.311

1

0.692

1

0.318

1

0.452

1

Diagnosisa

0.334

1

0.620

1

0.637

1

0.715

1

0.613

1

0.218

0.872

BMIa

0.620

1

0.376

1

0.510

1

0.848

1

0.754

1

0.665

1

Bhalla scoreb

0.942

1

0.808

1

0.158

0.632

0.830

1

0.324

1

0.311

1

Kanga scoreb

0.879

1

0.884

1

0.805

1

0.753

1

0.745

1

0.822

1

Shwachman-Kulczycki scoreb

0.985

1

0.416

1

0.151

0.604

0.538

1

0.837

1

0.981

1

Nasal polyposisa

0.582

1

0.347

1

0.285

1

0.457

1

0.631

1

0.986

1

Diabetes mellitusa

0.255

1

0.858

1

0.917

1

0.201

0.804

0.337

1

0.383

1

Osteoporosisa

0.562

1

0.829

1

0.108

0.432

0.339

1

0.036

0.144

0.713

1

Meconium ileus

0.420

1

0.389

1

0.379

1

0.130

0.520

0.080

0.320

0.619

1

Pancreatic insufficiencya

0.159

0.636

0.398

1

-

-

0.167

0.668

-

-

0.601

1

SpO2b

0.506

1

0.201

0.804

0.128

0.512

0.422

1

0.525

1

0.278

1

FVC(%)b

0.498

1

0.216

0.864

0.121

0.484

0.738

1

0.901

1

0.499

1

FEV1(%)b

0.668

1

0.214

0.856

0.201

0.804

0.479

1

0.731

1

0.769

1

FEV1/FVCb

0.615

1

0.592

1

0.671

1

0.407

1

0.686

1

0.373

1

FEF25–75%b

0.643

1

0.326

1

0.531

1

0.548

1

0.942

1

0.851

1

First P. aeruginosa a

0.147

0.588

0.125

0.500

0.341

1

0.146

0.584

0.027

0.108

0.264

1

P. aeruginosa mucoida

0.559

1

0.316

1

0.366

1

0.569

1

0.285

1

0.160

0.640

P. aeruginosa no mucoida

0.319

1

0.263

1

0.352

1

0.276

1

0.082

0.328

0.347

1

A. xylosoxidans a

0.327

1

0.018

0.072

0.013

0.052

0.687

1

0.646

1

0.006

0.024

S. aureus a

0.843

1

0.677

1

0.931

1

0.049

0.196

0.032

0.128

0.466

1

B. cepacia a

0.461

1

0.734

1

0.974

1

0.150

0.600

0.243

0.972

0.671

1

  1. aFisher’s exact test used for categorical variables; bStudent’s t-test used for numerical variables. P-values < 0.05 denote clinical association (bold).
  2. CFTR, Cystic fibrosis transmembrane regulator; GCLC, Glutamate cysteine ligase catalytic subunit; PI, Pancreatic insufficiency; BMI, Body mass index; SpO2, Hemoglobin oxygen saturation in the blood; FVC, Forced vital capacity; FEV1, Forced expiratory volume in the first second; FEF, Forced expiratory flow between 25 and 75% of vital capacity.
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BMC Medical Genetics

ISSN: 1471-2350

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