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Table 4 Canonical pathways enriched using 1956 genes from discovery set with adjusted p-value <0.05

From: Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1

Ingenuity canonical pathways -log(p) P (adj) Molecules
Molecular Mechanisms of Cancer 4.54 0.003 RAP2B,PLCB2,JAK1,DIRAS3,PIK3R1,SMAD3,TAB2,CCND1,MYC,PTK2, CTNNA2,CAMK2D,RHOG,RHOB….
Neuropathic Pain Signaling In Dorsal Horn Neurons 4.42 0.003 PLCB2,CAMK4,GRIA1,PIK3R1,GNA11,TAC1,GNA14,GRIA4,TACR1,CAMK2D,PIK3C3,CREB1,CAMK1G …
Calcium Signaling 4.24 0.003 RAP2B,CAMK4,CALM,GRIA1,TNNT2,HDAC9,CREB5,GRIA4,CABIN1,NFAT5,CAMK2D….
Cellular Effects of Sildenafil (Viagra) 4.2 0.003 PLCB2,CAMK4,CALM1,CACNA1S,PDE3A,GNA11,GNA14,PDE4D….
Glutamate Receptor Signaling 4.15 0.003 GRIN2B,CALML5,CAMK4,CALM1,SLC17A6,GRID2,GRIA1,GRIK3,SLC1A3,GRIA4,GNG7,….
Axonal Guidance Signaling 4.11 0.003 PLCB2,PIK3R1,NTN1,PTK2,NCK2,EPHB1,SEMA3D,UNC5D….
ILK Signaling 3.99 0.004 MAP2K6,TMSL3,PPP2R2A,PIK3R1,DIRAS3,BMP2,HIF1A,CREB5,CCND1,PGF,PTK2,NCK2,MYC….
Nitric Oxide Signaling in the Cardiovascular System 3.49 0.0108 PDE2A,CALML5,GUCY1B2,CACNA1D,CAMK4,CALM1,GUCY1A3,CACNA1S,PIK3R1….
Gap Junction Signaling 3.27 0.0150 PLCB2,PIK3R1,GNA11,GNA14,TUBB2B,SP3,ADCY5,PIK3C3,PRKAR1B,CAV1,PRKCE,CTNNB1,ACTC1….
Role of NFAT in Cardiac Hypertrophy 3.23 0.0150 MAP2K6,PLCB2,CAMK4,CALM1,PIK3R1,GNA11,HDAC9,GNA14….
BMP signaling pathway 3.19 0.0150 CAMK4,GRB2,RRAS,BMP2,SMAD6,SMAD7,ZNF423,BMPR1B,JUN,PRKAR2B,MAP3K7,CREB1,PRKAR1B….
Dopamine-DARPP32 Feedback in cAMP Signaling 3.17 0.0150 PLCB2,CAMK4,CALM1,PPP2R2A,CACNA1S,GNA11,GNA14,CREB5,KCNJ4,ADCY5,CREB1,PRKAR1B…
CREB Signaling in Neurons 3.07 0.0161 PLCB2,CAMK4,CALM1,PIK3R1,GRIA1,GRID2,GNA11,GNA14,CREB5,GRIA4,GNG7,GRIK5,CAMK2D,GRID1….
N-Glycan Biosynthesis 3.04 0.0161 B4GALT4,ALG2,MGAT4A,MAN1C1,B4GALT1,ST6GAL2,MAN1A1,MGAT5,MAN1A2,MAN2A1,B4GALT5,FUT4
cAMP-mediated signaling 3.04 0.0161 AKAP12,CAMK4,CALM1,PTGER3,PDE3A,TAAR1,CREB5,CHRM3,CHRM1,PDE4D,HTR1B,CAMK2D,ADCY5….
Factors Promoting Cardiogenesis in Vertebrates 2.98 0.0174 SMAD2,FZD10,NOX4,TCF4,BMP2,FZD1,TCF3,FZD8,BMPR1B,MAP3K7 (includes EG:172842),PRKCE….
Melatonin Signaling 2.89 0.0201 MAP2K6,CALML5,PLCB2,CAMK4,MTNR1A,CALM1,GNA11,PLCL2,GNA14,CAMK2D,PRKAR2B,RORA….
Synaptic Long Term Potentiation 2.77 0.0235 GRIN2B,CALML5,PLCB2,CAMK4,CALM1,RRAS,GRIA1,GNA11,ITPR1,CREB5,GRIA4,GRIN3A,GRM7….
Amyotrophic Lateral Sclerosis Signaling 2.75 0.0235 GRIN2B,CACNA1D,GDNF,CAPN11,GRID2,CACNA1S,GRIA1,PIK3R1,GRIK3,GRIA4,GRIN3A,PGF,GRIK5….
Phospholipase C Signaling 2.73 0.0235 PLCB2,CAMK4,CALM1,DIRAS3,HDAC9,PLA2G2A,CREB5,GNG7,PLA2G4E,RHOG,NFAT5,RHOB,ADCY5….
PI3K Signaling in B Lymphocytes 2.73 0.0235 PLCB2,CAMK4,CALM1,PIK3R1,GNA11,GNA14,PTPRC,NFAT5,JUN,CAMK2D,CREB1,IRS2,PPP3CA….
Synaptic Long Term Depression 2.7 0.0241 PLCB2,PPP2R2A,GRID2,GRIA1,GNA11,PLA2G2A,GNA14,GRIA4,PLA2G4E,GRID1….
PPARα/RXRα Activation 2.6 0.0290 MAP2K6,PLCB2,NCOA6,SMAD3,GNA11,GNA14,IL6,CHD5,JUN,MAP3K7,ADCY5,PRKAR1B,PRKAA1….
TGF-β Signaling 2.44 0.0386 MAP2K6,SMAD2,INHA,GRB2,RRAS,BMP2,SMAD3,SMAD6,SMAD7,ZNF423,GSC,BMPR1B,PIAS4….
Protein Kinase A Signaling 2.44 0.0386 PLCB2,PDE3A,SMAD3,CREB5,PDE4D,NTN1,PTK2,CAMK2D,ADCY5,RYR3,PDE2A,YWHAE,PTCH1….
N-Glycan Degradation 2.38 0.0426 MANEA,GBA3,MAN1C1,SI,MAN1A1,HEXB,MAN1A2,MAN2A1
Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes 2.36 0.0430 VAV2,SMAD2,CALML5,CAMK4,CALM1,GRB2,RRAS,SMAD3,MALT1,NFAT5,JUN,VAV3,ZAP70,MAPK10….
Wnt/β-catenin Signaling 2.32 0.0454 FZD10,TCF4,PPP2R2A,TLE1,FZD1,SOX13,CCND1,SOX2,MYC,SOX9,JUN,NLK,MAP3K7….
Agrin Interactions at Neuromuscular Junction 2.26 0.0498 RRAS,ITGA6,ITGA3,LAMC1,PTK2,JUN,NRG3,ERBB4,MUSK,LAMB1,MAPK10….
Colorectal Cancer Metastasis Signaling 2.25 0.0498 FZD10,TCF4,JAK1,PTGER3,PIK3R1,DIRAS3,MMP16,SMAD3,FZD1,IL6,CCND1,GNG7,BIRC5,PGF….
  1. Ingenuity Pathway Analysis of the 1956 genes identified 30 significantly enriched pathways.
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