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Table 1 SNPs showing suggestive association (p < 0.0001) to BD in our combined (CAMH and IoP) GWAS

From: Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1

Chr

SNP

bp

A1/A2

MAF

MAF_UK

MAF_CAN

P (UnAdj)

OR (UnAdj)

P (Adj)

OR (Adj)

P_UK

P_CAN

Gene

1

rs2813164

96688031

C/T

0.3017

0.286

0.3195

3.75E-04

1.295

5.67E-05

1.349

0.07331

0.001371

Y0062a

3

rs11708571

21591377

G/A

0.3062

0.3163

0.2938

1.82E-04

0.7633

8.66E-05

0.7485

5.27E-05

0.2652

ZNF659b,c,d

4

rs4689410

6344204

A/G

0.3434

0.3569

0.3275

2.04E-05

0.7418

5.96E-06

0.7264

0.01966

0.0002366

PPP2R2Ce,f

6

rs215006

152755628

A/G

0.2281

0.2095

0.2185

2.78E-04

1.335

7.83E-05

1.38

0.003807

0.001586

SYNE1c

6

rs214972

152775813

T/C

0.2271

0.2219

0.2327

4.73E-05

1.383

1.66E-05

1.419

0.003363

0.005299

SYNE1c

6

rs2623971

152831067

A/G

0.2107

0.2225

0.2348

1.86E-05

1.42

3.52E-06

1.481

0.004044

0.02257

SYNE1c

6

rs2623966

152853674

C/T

0.2122

0.2076

0.2173

1.50E-05

1.424

3.02E-06

1.481

0.002348

0.002308

SYNE1c

6

rs2141150

152868632

C/A

0.2138

0.2063

0.2155

1.73E-05

1.419

3.33E-06

1.476

0.002484

0.002721

SYNE1c

6

rs2695261

152869726

C/T

0.2069

0.2022

0.212

2.32E-05

1.417

4.12E-06

1.476

0.006699

0.001146

SYNE1c

9

rs7864144

101406038

G/A

0.1284

0.1294

0.1268

4.85E-04

0.7059

8.05E-05

0.6674

0.0008592

0.1271

GABBR2f,h

10

rs12773173

30011304

T/C

0.1028

0.1698

0.2155

1.26E-05

0.6902

6.56E-05

0.7054

0.02562

8.22E-05

SVILg

19

rs1483651

58689834

C/A

0.1914

0.2857

0.2734

9.70E-06

1.389

7.55E-06

1.41

0.05476

1.10E-05

ZNF274c

19

rs4444432

58715538

G/T

0.2801

0.2868

0.2741

5.58E-06

1.402

4.85E-06

1.419

0.05396

4.94E-06

ZNF274c

19

rs7256349

58718269

A/G

0.281

0.3041

0.2839

4.09E-05

1.349

4.51E-05

1.359

0.03677

0.0001753

ZNF274c

  1. aSNP or locus positive in [29].
  2. bSNP or locus positive in [61].
  3. cSNP or locus positive in [37].
  4. dSNP or locus positive in [28].
  5. eSNP or locus positive in [36].
  6. fSNP or locus positive in Gurling-UCL top 1000 (personal communication).
  7. gSNP or locus positive in [61].
  8. hSNP or locus positive in [69].
  9. Only SNPs included if located at genes with previous GWAS bipolar disorder associations. Chr = chromosome; SNP = single nucleotide polymorphism; bp = base pair (position from p telomere, according to NCBI36/hg18); A1 = allele 1; A2 = allele 2; MAF = minor allele frequency, (also for UK and Canadian (CAN) sets); P(UnAdj) = unadjusted p-value; OR(UnAdj) = unadjusted odds ratio; P(Adj) = adjusted p-value; OR(Adj) = adjusted odds ratio; Gene indicates SNP lies within a known gene. Full list of 68 SNPs showing suggestive association (p < 0.0001) is given in Additional file 1: Table S2.