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Table 1 SNPs showing suggestive association (p < 0.0001) to BD in our combined (CAMH and IoP) GWAS

From: Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1

Chr SNP bp A1/A2 MAF MAF_UK MAF_CAN P (UnAdj) OR (UnAdj) P (Adj) OR (Adj) P_UK P_CAN Gene
1 rs2813164 96688031 C/T 0.3017 0.286 0.3195 3.75E-04 1.295 5.67E-05 1.349 0.07331 0.001371 Y0062a
3 rs11708571 21591377 G/A 0.3062 0.3163 0.2938 1.82E-04 0.7633 8.66E-05 0.7485 5.27E-05 0.2652 ZNF659b,c,d
4 rs4689410 6344204 A/G 0.3434 0.3569 0.3275 2.04E-05 0.7418 5.96E-06 0.7264 0.01966 0.0002366 PPP2R2Ce,f
6 rs215006 152755628 A/G 0.2281 0.2095 0.2185 2.78E-04 1.335 7.83E-05 1.38 0.003807 0.001586 SYNE1c
6 rs214972 152775813 T/C 0.2271 0.2219 0.2327 4.73E-05 1.383 1.66E-05 1.419 0.003363 0.005299 SYNE1c
6 rs2623971 152831067 A/G 0.2107 0.2225 0.2348 1.86E-05 1.42 3.52E-06 1.481 0.004044 0.02257 SYNE1c
6 rs2623966 152853674 C/T 0.2122 0.2076 0.2173 1.50E-05 1.424 3.02E-06 1.481 0.002348 0.002308 SYNE1c
6 rs2141150 152868632 C/A 0.2138 0.2063 0.2155 1.73E-05 1.419 3.33E-06 1.476 0.002484 0.002721 SYNE1c
6 rs2695261 152869726 C/T 0.2069 0.2022 0.212 2.32E-05 1.417 4.12E-06 1.476 0.006699 0.001146 SYNE1c
9 rs7864144 101406038 G/A 0.1284 0.1294 0.1268 4.85E-04 0.7059 8.05E-05 0.6674 0.0008592 0.1271 GABBR2f,h
10 rs12773173 30011304 T/C 0.1028 0.1698 0.2155 1.26E-05 0.6902 6.56E-05 0.7054 0.02562 8.22E-05 SVILg
19 rs1483651 58689834 C/A 0.1914 0.2857 0.2734 9.70E-06 1.389 7.55E-06 1.41 0.05476 1.10E-05 ZNF274c
19 rs4444432 58715538 G/T 0.2801 0.2868 0.2741 5.58E-06 1.402 4.85E-06 1.419 0.05396 4.94E-06 ZNF274c
19 rs7256349 58718269 A/G 0.281 0.3041 0.2839 4.09E-05 1.349 4.51E-05 1.359 0.03677 0.0001753 ZNF274c
  1. aSNP or locus positive in [29].
  2. bSNP or locus positive in [61].
  3. cSNP or locus positive in [37].
  4. dSNP or locus positive in [28].
  5. eSNP or locus positive in [36].
  6. fSNP or locus positive in Gurling-UCL top 1000 (personal communication).
  7. gSNP or locus positive in [61].
  8. hSNP or locus positive in [69].
  9. Only SNPs included if located at genes with previous GWAS bipolar disorder associations. Chr = chromosome; SNP = single nucleotide polymorphism; bp = base pair (position from p telomere, according to NCBI36/hg18); A1 = allele 1; A2 = allele 2; MAF = minor allele frequency, (also for UK and Canadian (CAN) sets); P(UnAdj) = unadjusted p-value; OR(UnAdj) = unadjusted odds ratio; P(Adj) = adjusted p-value; OR(Adj) = adjusted odds ratio; Gene indicates SNP lies within a known gene. Full list of 68 SNPs showing suggestive association (p < 0.0001) is given in Additional file 1: Table S2.
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