TY - JOUR AU - Vymetalkova, Veronika Polakova AU - Slyskova, Jana AU - Korenkova, Vlasta AU - Bielik, Ludovit AU - Langerova, Lucie AU - Prochazka, Pavel AU - Rejhova, Alexandra AU - Schwarzova, Lucie AU - Pardini, Barbara AU - Naccarati, Alessio AU - Vodicka, Pavel PY - 2014 DA - 2014/01/31 TI - Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients JO - BMC Medical Genetics SP - 17 VL - 15 IS - 1 AB - Mismatch repair (MMR) genes are known to be frequently altered in colorectal cancer (CRC). Both genetics and epigenetics modifications seems to be relevant in this phenomenon, however it is still not clear how these two aspects are interconnected. The present study aimed at characterizing of epigenetic and gene expression profiles of MMR genes in sporadic CRC patients from the Czech Republic, a country with one of the highest incidences of this cancer all over Europe. SN - 1471-2350 UR - https://doi.org/10.1186/1471-2350-15-17 DO - 10.1186/1471-2350-15-17 ID - Vymetalkova2014 ER -