Skip to main content

Table 3 Meta-analysis of selected candidate SNPs and fasting glucose and natural log insulin, by racial/ethnic group

From: Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study

  

Coded

European Americans

African Americans

Hispanics

Phenotype

SNP

Allele

Effect Size (95% CI)*

P-value

N

Power

Effect Size (95% CI)*

P-value

N

Power

Effect Size (95% CI)*

P-value

N

Power

glucose

rs11708067

A

0.068 (0.013 - 0.123)

2.0E-02

9323

0.86

0.151 (-0.064 - 0.366)

1.7E-01

3080

0.34

    

(mmol/L)

rs560887

C

0.072 (0.054 - 0.090)

9.0E-15

14946

0.99

0.041 (-0.025 - 0.106)

2.3E-01

4857

0.70

0.100 (0.051 - 0.149)

5.5E-05

1666

0.64

 

rs4607517

A

0.061 (0.030 - 0.093)

1.6E-04

2916

0.95

0.025 (-0.111 - 0.160)

7.2E-01

456

0.13

    
 

rs780094

C

0.050 (0.036 - 0.064)

1.2E-12

21608

0.99

0.026 (-0.014 - 0.065)

2.0E-01

5699

0.51

0.063 (0.029 - 0.098)

2.7E-05

1992

0.38

 

rs7944584

A

0.055 (0.002 - 0.108)

4.0E-02

9191

0.72

-0.177 (-0.544 - 0.191)

3.5E-01

3037

0.09

    
 

rs10830963

G

0.063 (0.043 - 0.083)

9.5E-10

16883

0.99

0.096 (0.043 - 0.149)

3.7E-04

6234

0.92

0.076 (0.040 - 0.112)

3.3E-05

2223

0.97

 

rs11558471

A

0.080 (0.033 - 0.126)

7.8E-04

10741

0.96

-0.138 (-0.386 - 0.111)

2.8E-01

3447

0.19

    
 

rs4506565

T

0.107 (0.059 - 0.154)

9.8E-06

10644

0.88

0.160 (0.013 - 0.306)

3.0E-02

3425

0.35

    
 

rs7903146

T

0.052 (0.014 - 0.052)**

7.1E-03

21710

0.99

0.050 (0.022 - 0.078)

5.9E-05

7469

0.54

0.010 (-0.026 - 0.046)

5.7E-01

2611

0.28

(ln)insulin

rs780094

C

0.034 (0.024 - 0.044)

1.3E-10

20945

0.14

0.022 (-0.006 - 0.050)

1.2E-01

5648

0.06

0.039 (0.008 - 0.070)

1.3E-02

1975

0.06

(pmol/L)

rs35767

G

0.018 (-0.005 - 0.040)

1.3E-01

10741

0.05

0.022 (-0.011 - 0.057)

1.8E-01

3446

0.05

    
  

Coded

American Indians

East Asians

Original GWAS Report

Phenotype

SNP

Allele

Effect Size (95% CI)*

P-value

N

Power

Effect Size (95% CI)*

P-value

N

Power

Reference

Effect Size (95% CI)

glucose

rs11708067

A

        

Dupuis et al. †

0.027 (0.021 – 0.033)

(mmol/L)

rs560887

C

0.128 (-0.047 - 0.303)***

1.5E-01

1298

0.28

    

Bouatia-Naji et al.

0.060 (0.050 – 0.080)

 

rs4607517

A

0.053 (0.006 - 0.100)

2.8E-02

1282

0.63

    

Prokopenko et al.

0.062 (0.048 - 0.076)

 

rs780094

C

0.048 (0.003 - 0.093)

3.6E-02

1739

0.25

0.063 (0.006 - 0.121)

3.1E-02

736

0.17

Dupuis et al. †

0.029 (0.023 - 0.035)

 

rs7944584

A

        

Dupuis et al. †

0.021 (0.015 - 0.027)

 

rs10830963

G

        

Prokopenko et al.

0.072 (0.062 - 0.082)

 

rs11558471

A

        

Dupuis et al. † ‡

0.027 (0.019 - 0.035)

 

rs4506565

T

        

Dupuis et al. † §

0.023 (0.015 - 0.031)

 

rs7903146

T

-0.037 (-0.096 - 0.023)

2.3E-01

1738

0.11

-0.033 (-0.181 - 0.114)

6.6E-01

758

0.06

Dupuis et al. †

0.023 (0.015 - 0.031)

(ln)insulin

rs780094

C

0.080 (0.035 - 0.125)

4.8E-04

1697

0.05

0.026 (-0.033 - 0.085)

3.9E-01

689

0.05

Dupuis et al. †

0.032 (0.024 - 0.040)

(pmol/L)

rs35767

G

        

Dupuis et al. †

0.010 (-0.002 - 0.022)

  1. CI: confidence interval; *Effect size is calculated for coded allele relative to non-coded allele; † effect size from replication cohort, as effect size was not reported for discovery cohort; ‡ effect size reported for rs13266634, a SNP in LD with rs11558471 (r2 = 0.96); § effect size reported for rs7903146, a SNP in LD with rs4506565 (r2 = 0.92);**heterogeneity p-value = 0.001, χ2 = 18.79 in a fixed effects model, so results from a random effects model are shown; ***heterogeneity p-value = 0.03, χ2 = 7.31 in a fixed effects model, so results from a random effects model are shown.
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us