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Table 3 Meta-analysis of selected candidate SNPs and fasting glucose and natural log insulin, by racial/ethnic group

From: Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study

   Coded European Americans African Americans Hispanics
Phenotype SNP Allele Effect Size (95% CI)* P-value N Power Effect Size (95% CI)* P-value N Power Effect Size (95% CI)* P-value N Power
glucose rs11708067 A 0.068 (0.013 - 0.123) 2.0E-02 9323 0.86 0.151 (-0.064 - 0.366) 1.7E-01 3080 0.34     
(mmol/L) rs560887 C 0.072 (0.054 - 0.090) 9.0E-15 14946 0.99 0.041 (-0.025 - 0.106) 2.3E-01 4857 0.70 0.100 (0.051 - 0.149) 5.5E-05 1666 0.64
  rs4607517 A 0.061 (0.030 - 0.093) 1.6E-04 2916 0.95 0.025 (-0.111 - 0.160) 7.2E-01 456 0.13     
  rs780094 C 0.050 (0.036 - 0.064) 1.2E-12 21608 0.99 0.026 (-0.014 - 0.065) 2.0E-01 5699 0.51 0.063 (0.029 - 0.098) 2.7E-05 1992 0.38
  rs7944584 A 0.055 (0.002 - 0.108) 4.0E-02 9191 0.72 -0.177 (-0.544 - 0.191) 3.5E-01 3037 0.09     
  rs10830963 G 0.063 (0.043 - 0.083) 9.5E-10 16883 0.99 0.096 (0.043 - 0.149) 3.7E-04 6234 0.92 0.076 (0.040 - 0.112) 3.3E-05 2223 0.97
  rs11558471 A 0.080 (0.033 - 0.126) 7.8E-04 10741 0.96 -0.138 (-0.386 - 0.111) 2.8E-01 3447 0.19     
  rs4506565 T 0.107 (0.059 - 0.154) 9.8E-06 10644 0.88 0.160 (0.013 - 0.306) 3.0E-02 3425 0.35     
  rs7903146 T 0.052 (0.014 - 0.052)** 7.1E-03 21710 0.99 0.050 (0.022 - 0.078) 5.9E-05 7469 0.54 0.010 (-0.026 - 0.046) 5.7E-01 2611 0.28
(ln)insulin rs780094 C 0.034 (0.024 - 0.044) 1.3E-10 20945 0.14 0.022 (-0.006 - 0.050) 1.2E-01 5648 0.06 0.039 (0.008 - 0.070) 1.3E-02 1975 0.06
(pmol/L) rs35767 G 0.018 (-0.005 - 0.040) 1.3E-01 10741 0.05 0.022 (-0.011 - 0.057) 1.8E-01 3446 0.05     
   Coded American Indians East Asians Original GWAS Report
Phenotype SNP Allele Effect Size (95% CI)* P-value N Power Effect Size (95% CI)* P-value N Power Reference Effect Size (95% CI)
glucose rs11708067 A          Dupuis et al. † 0.027 (0.021 – 0.033)
(mmol/L) rs560887 C 0.128 (-0.047 - 0.303)*** 1.5E-01 1298 0.28      Bouatia-Naji et al. 0.060 (0.050 – 0.080)
  rs4607517 A 0.053 (0.006 - 0.100) 2.8E-02 1282 0.63      Prokopenko et al. 0.062 (0.048 - 0.076)
  rs780094 C 0.048 (0.003 - 0.093) 3.6E-02 1739 0.25 0.063 (0.006 - 0.121) 3.1E-02 736 0.17 Dupuis et al. † 0.029 (0.023 - 0.035)
  rs7944584 A          Dupuis et al. † 0.021 (0.015 - 0.027)
  rs10830963 G          Prokopenko et al. 0.072 (0.062 - 0.082)
  rs11558471 A          Dupuis et al. † ‡ 0.027 (0.019 - 0.035)
  rs4506565 T          Dupuis et al. † § 0.023 (0.015 - 0.031)
  rs7903146 T -0.037 (-0.096 - 0.023) 2.3E-01 1738 0.11 -0.033 (-0.181 - 0.114) 6.6E-01 758 0.06 Dupuis et al. † 0.023 (0.015 - 0.031)
(ln)insulin rs780094 C 0.080 (0.035 - 0.125) 4.8E-04 1697 0.05 0.026 (-0.033 - 0.085) 3.9E-01 689 0.05 Dupuis et al. † 0.032 (0.024 - 0.040)
(pmol/L) rs35767 G          Dupuis et al. † 0.010 (-0.002 - 0.022)
  1. CI: confidence interval; *Effect size is calculated for coded allele relative to non-coded allele; † effect size from replication cohort, as effect size was not reported for discovery cohort; ‡ effect size reported for rs13266634, a SNP in LD with rs11558471 (r2 = 0.96); § effect size reported for rs7903146, a SNP in LD with rs4506565 (r2 = 0.92);**heterogeneity p-value = 0.001, χ2 = 18.79 in a fixed effects model, so results from a random effects model are shown; ***heterogeneity p-value = 0.03, χ2 = 7.31 in a fixed effects model, so results from a random effects model are shown.