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Table 3 Associations of CAPN10 haplotypes with type 2 diabetes in urban Ghana

From: The TCF7L2 rs7903146 (T) allele is associated with type 2 diabetes in urban Ghana: a hospital-based case–control study

Haplotypea

Genotype

N

Controls

Type 2 diabetes

OR (95% CI)

P

aOR (95% CI)b

P

111

n

1048

374

674

    
 

- -

608

219 (58.6)

389 (57.7)

Reference

   
 

111 -

376

140 (37.4)

236 (35.0)

    
 

111 111

64

15 (4.0)

49 (7.3)

1.12 (0.91–1.38)

0.30

1.00 (0.75–1.34)

0.98

 

Frequency

 

0.23

0.25

    

112

n

1048

374

674

    
 

- -

224

82 (21.9)

142 (21.1)

Reference

   
 

112 -

544

183 (48.9)

361 (53.6)

    
 

112 112

280

109 (29.1)

171 (25.4)

0.94 (0.78–1.13)

0.51

0.95 (0.74–1.22)

0.67

 

Frequency

 

0.54

0.52

    

121

n

1048

374

674

    
 

- -

823

296 (79.1)

527 (78.2)

Reference

   
 

121 -

205

72 (19.3)

133 (19.7)

    
 

121 121

20

6 (1.6)

14 (2.1)

1.07 (0.81–1.40)

0.64

1.40 (0.99–1.99)

0.06

 

Frequency

 

0.11

0.12

    

122

n

1048

374

674

    
 

- -

1039

372 (99.5)

667 (99.0)

Reference

   
 

122 -

9

2 (0.5)

7 (1.0)

    
 

122 122

0

0 (0.0)

0 (0.0)

1.95 (0.40–9.44)

0.41

3.87 (0.61–24.52)

0.15

 

Frequency

 

0.01

0.01

    

221

n

1048

374

674

    
 

- -

853

298 (79.7)

555 (82.3)

Reference

   
 

221 -

186

72 (19.3)

114 (16.9)

    
 

221 221

9

4 (1.1)

5 (0.7)

0.84 (0.63–1.14)

0.27

0.73 (0.48–1.10)

0.13

 

Frequency

 

0.11

0.09

    

211

n

1048

374

674

    
 

- -

1041

369 (98.7)

672 (99.7)

Reference

   
 

211 -

7

5 (1.3)

2 (0.3)

    
 

211 211

0

0 (0.0)

0 (0.0)

0.22 (0.04–1.14)

0.07

0.32 (0.03–2.92)

0.31

 

Frequency

 

0.01

0.001

    

212

n

1048

374

674

    
 

- -

1043

372 (99.5)

671 (99.6)

Reference

   
 

212 -

5

2 (0.5)

3 (0.4)

    
 

212 212

0

0 (0.0)

0 (0.0)

0.83 (0.14–5.00)

0.84

-

/

 

Frequency

 

0.003

0.002

    

222

N

1048

374

674

    
 

- -

1030

370 (98.9)

660 (97.9)

Reference

   
 

222 -

18

4 (1.2)

14 (2.1)

    
 

222 222

0

0 (0.0)

0 (0.0)

1.96 (0.64–6.00)

0.24

1.20 (0.28–5.04)

0.81

 

Frequency

 

0.01

0.01

    
  1. a, Haplotypes were constructed from genotype data using the software package PHASE version 2.1 [23, 24].
  2. b, Adjusted for age, gender, BMI ≥25.0 kg/m2 and hypertension status.