Genotype Count | ||||||
---|---|---|---|---|---|---|
rs545358 | rs319013 | rs76547469 | ||||
GG:GT:TT | CC:CA:AA | TT:TA:AA | ||||
sCJD (n = 109) | 15:3:91 | 48:24:37 | 99:2:8 | |||
vCJD (n = 120) | 49:3:68 | 52:21:47 | 110:3:7 | |||
1000 Genomes (n = 379) | 1:41:337 | n/a | n/a | |||
Exome Variant Server (n = 4241) | n/a | 599:1894:1748 | 3838:428:17 | |||
Fisher's Test Results for sCJD and vCJD versus Online Controls | ||||||
Test | dbSNP Identifier | Genotype/Allele Comparison | p value | Odds Ratio | 95% Confidence Interval | Significance1 |
sCJD vs. vCJD | ||||||
rs545358 | G vs. T | 2.04E-10 | 0.246 | 0.151 - 0.393 | *** | |
GG vs. TT | 6.46E-06 | 0.230 | 0.110 - 0.459 | *** | ||
GG vs. GT | 0.172 | 0.312 | 0.038 - 2.579 | |||
rs319013 | C vs. A | 0.5738 | 1.126 | 0.767 - 1.655 | ||
CC vs. AA | 0.6568 | 1.172 | 0.629 - 2.190 | |||
CC vs. CA | 0.5933 | 0.809 | 0.375 - 1.734 | |||
rs76547469 | T vs. A | 0.7255 | 0.847 | 0.398 - 1.795 | ||
TT vs. AA | 0.7906 | 0.788 | 0.234 - 2.589 | |||
TT vs. TA | 1 | 1.348 | 0.151 - 16.444 | |||
sCJD vs. Controls | ||||||
rs545358 | G vs. T | 2.01E-05 | 2.962 | 1.769 - 4.923 | *** | |
GG vs. TT | 2.69E-09 | 55.001 | 8.253 - 2315.479 | *** | ||
GG vs. GT | 2.30E-10 | 163.748 | 17.131 - 8175.872 | *** | ||
rs319013 | C vs. A | 4.69E-08 | 2.134 | 1.615 - 2.827 | *** | |
CC vs. AA | 4.22E-09 | 3.783 | 2.387 - 6.038 | *** | ||
CC vs. CA | 6.73E-14 | 6.318 | 3.758 - 10.882 | *** | ||
rs76547469 | T vs. A | 0.07015 | 0.633 | 0.386 - 1.101 | ||
TT vs. AA | 1.61E-07 | 0.055 | 0.022 - 0.151 | *** | ||
TT vs. TA | 0.003525 | 5.519 | 1.478 - 46.367 | ** | ||
vCJD vs. Controls | ||||||
rs545358 | G vs. T | < 2.2e-16 | 12.038 | 7.957 - 18.471 | *** | |
GG vs. TT | < 2.2e-16 | 237.889 | 39.562 - 9180.580 | *** | ||
GG vs. GT | < 2.2e-16 | 530.747 | 60.122 - 16384.000 | *** | ||
rs319013 | C vs. A | 1.25E-06 | 1.894 | 1.452 - 2.471 | *** | |
CC vs. AA | 3.56E-08 | 3.227 | 2.108 - 4.951 | *** | ||
CC vs. CA | < 2.2e-16 | 7.834 | 4.593 - 13.812 | *** | ||
rs76547469 | T vs. A | 0.2474 | 0.748 | 0.452 - 1.318 | ||
TT vs. AA | 3.67E-06 | 0.070 | 0.027 - 0.203 | *** | ||
TT vs. TA | 0.005828 | 4.088 | 1.353 - 20.212 | ** | ||
Significance | * 0.05 - 0.001 | ** 0.001 - 0.0001 | *** <0.0001 |