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Table 3 Attempted replication of top results in independent populations

From: ITGB5 and AGFG1 variants are associated with severity of airway responsiveness

 

SHARP

LHS

DAG

  

SNP

P-value

Beta

P-value

Beta

P-value

Fisher combined P-value

AGFG1 eQTL P-value in CAMP

rs6731443

2.5E-06

−0.022

0.012

−0.026

0.39

2.14E-06

0.0067

rs13382948

2.6E-06

0.021

0.015

0.026

0.39

2.75E-06

0.0067

rs10189795

3.8E-06

0.022

0.012

0.030

0.37

2.97E-06

0.0052

rs4972983

9.0E-06

−0.021

0.017

−0.034

0.35

8.62E-06

0.0052

rs4485561

9.8E-06

0.020

0.022

0.034

0.35

1.15E-05

0.0052

rs848788

7.2E-07

−0.009

0.20

0.027

0.61

1.30E-05

-

rs11683662

9.3E-06

−0.020

0.025

0.043

0.68

2.21E-05

-

rs7579157

9.4E-06

0.019

0.025

−0.041

0.67

2.23E-05

-

rs7595130

9.5E-06

0.019

0.025

−0.040

0.67

2.24E-05

-

rs7592613

9.3E-06

−0.020

0.026

0.042

0.68

2.25E-05

-

rs4129709

9.7E-06

−0.019

0.025

0.045

0.69

2.27E-05

0.034

rs11674314

9.6E-06

0.019

0.025

−0.041

0.68

2.27E-05

0.034

rs614664

6.0E-06

−0.011

0.14

0.041

0.67

6.73E-05

-

rs702036

7.1E-06

0.011

0.14

−0.037

0.65

7.58E-05

-

rs4861175

4.9E-06

0.003

0.60

0.077

0.92

2.60E-04

-

rs296282

8.0E-06

0.001

0.46

-

-

-

-

  1. Reference alleles are those listed in Table 2. For eQTL, the gene for which transcripts are differentially expressed based on the corresponding SNP is AGFG1. SNPs with no listed eQTL P-values do not meet nominal significance (i.e. P-value >0.05) for any gene.
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BMC Medical Genetics

ISSN: 1471-2350

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