Figure 1
From: DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets
CpG sites analysed in this study and DNA methylation difference of CpG site +199/+205. A) Schematic figure showing the CpG sites in regions upstream and downstream of transcription start site (marked with an arrow and +1) of the GLP1R gene analysed in this study. The positions of the specific CpG sites are indicated in relationship to the transcription start site. One previously known transcription factor binding site that co-localises with CpG site −376 is indicated above the specific CpG site. CpG sites +199 and +205 were analysed as a unit, which is marked with brackets. B) The degree of DNA methylation of CpG site +199/+205 in non-diabetic and type 2 diabetic islets. Data are expressed as mean ± SEM. (* p<0.05).