Interactive effect of STAT6 and IL13gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study

Table 3 Interaction and combined effects of IL13 (rs20541) and STAT6 (rs1059513) single nucleotide polymorphisms on eczema risk: results from IOW and PAPA studies

IOW (discovery) study^†– Dominant model
Variable	Coefficient	RR^$	95% CI	p-value
IL13 (AG/AA vs. GG)	−0.008	0.99	0.53 – 1.09	0.952
STAT6 (TC/CC vs. TT)	−0.278	0.76	0.77 – 1.27	0.135
Interaction (IL13 × STAT6)	0.630	1.88	1.10 – 3.19	0.046^£
Combined effect – Modeling^*	0.344	1.41	0.98 – 2.03	0.063
Combined effect – Stratification^¶	0.418	1.52	1.05 – 2.20	0.028
PAPA (replication) Study – Dominant model
IL13 (AG/AA vs. GG)	−0.043	0.96	0.64 – 1.43	0.833
STAT6 (TC/CC vs. TT)	−0.025	0.98	0.60 – 1.58	0.920
Interaction (IL13 × STAT6)	0.754	2.13	1.05 – 4.31	0.037
Combined effect – Modeling^‡	0.686	1.99	1.27 – 3.11	0.003
Combined effect – Stratification^¶	0.698	2.01	1.29 – 3.12	0.002

^† Association results for the IOW study were based on repeated measurement analysis (GEE models), which utilized data collected at the 1-or-2, 4, 10, and 18 years follow-ups.
^$ Association adjusted for gender and age at follow up.
^£ Adjusted for multiple testing using the false discovery rate method p-value.
^* Combined effect – Modeling RR was estimated as: RR = exp(−0.008 – 0.278 + 0.630).
^‡ Combined effect – Modeling RR was estimated as: RR = exp(−0.043 – 0.025 + 0.754).
^¶ Combined effect – Stratification RR was estimated by pooling together individuals with risk genotypes for both SNPs and those with non-risk genotypes formed the referent group.

ISSN: 1471-2350