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Table 2 Associations of IL13 and STAT6 SNPs genotypes with eczema: results from IOW and PAPA studies

From: Interactive effect of STAT6 and IL13gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study

Gene (SNP rs no.)

Model

Genotype

Eczema % (n/total)

RR†

95% CI

IL13 (rs20541)

     

IOW study‡

Co-dominant

GG

12.8 (357/2781)

1.00

–

  

AG

14.3 (194/1357)

1.10

0.88 – 1.38

  

AA

16.9 (24/142)

1.37

0.83 – 2.25

   

p-trend *

0.08

 
 

Dominant

GG

12.8 (357/2781)

1.00

–

  

AG/AA

14.5 (218/1499)

1.13

0.91 – 1.40

PAPA study

Co-dominant

GG

9.5 (92/967)

1.00

–

  

AG

12.3 (49/397)

1.27

0.92 – 1.76

  

AA

11.6 (5/43)

1.14

0.49 – 2.68

   

p-trend *

0.147

 
 

Dominant

GG

9.5 (92/967)

1.00

–

  

AG/AA

12.3 (54/440)

1.26

0.91 – 1.73

STAT6 (rs1059513)

     

IOW study‡

Co-dominant

TT

13.6 (467/3438)

1.00

–

  

TC

12.8 (106/830)

0.92

0.70– 1.20

  

CC

28.6 (12/42)

2.21

1.05 – 4.66$

   

p-trend *

0.54

 
 

Dominant

TT

13.6 (467/3438)

1.00

–

  

TC/CC

13.5 (118/872)

0.98

0.75 – 1.27

PAPA study

Co-dominant

TT

9.8 (106/1082)

1.00

–

  

TC

12.3 (38/308)

1.33

0.94 – 1.88

  

CC

10.5 (2/19)

1.16

0.31 – 4.30

   

p-trend *

0.243

 
 

Dominant

TT

9.8 (106/1082)

1.00

–

  

TC/CC

12.2 (40/327)

1.32

0.93 – 1.86

  1. † Association adjusted for gender and age at follow up.
  2. * Based on Cochran-Armitage Trend Test.
  3. ‡ Association results for the IOW study were based on repeated measurement analysis (GEE models), which utilized data collected at the 1-or-2, 4, 10, and 18 years follow-ups.
  4. $ The association was not statistically significant after adjusting for multiple testing (adjusted p-value = 0.857).