Table 8 Serum cytokine levels in relation to their genotypes and alleles among IPF patients and healthy controls
From: Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis
Cytokine/genotype/ Allele | Producer | n | IPF | n | Healthy controls | *p-value |
|---|---|---|---|---|---|---|
TNF-α | ||||||
  GG | Low | 21 | 1.37 (0 – 19.68) | 24 | 11.22 (0 – 64.07) | 0.226 |
  GA | High | 13 | 6.82 (0 – 26.90) | 12 | 8.64 (0 – 11.58) | 0.511 |
  AA | High | 4 | 9.99 (1.27 – 13.10) | - |  |  |
  G allele |  | 34 | 2.35 (0 – 26.9) | 36 | 10.81 (0 – 64.07) | 0.194 |
  A allele |  | 17 | 7.89 (0 – 26.9) | 12 | 8.64 (0 – 11.58) | 0.293 |
IL-6 | ||||||
  GG | High | 27 | 3.44 (0 – 32.35) | 24 | 0 (0 – 267.38) | <0.0001 |
  GC | High | 8 | 6.45 (0.57 – 15.41) | 8 | 0 (0 – 0.58) | <0.0001 |
  CC | Low | 3 | 14.1 (4.80 – 16.11) | 4 | 0 | 0.057 |
  G allele |  | 35 | 3.61 (0 – 32.35) | 32 | 0 (0 – 267.38) | <0.0001 |
  C allele |  | 11 | 9.52 (0.57 – 16.11) | 12 | 0 (0 – 0.58) | <0.0001 |
IL-10 | ||||||
  GCC GCC | High | 6 | 4.99 (0 – 11.27) | 7 | 0.56 (0 – 2.03) | 0.031 |
  GCC ACC | Intermediate | 8 | 3.61 (0 – 7.16) | 6 | 1.44 (0 – 3.38) | 0.090 |
  GCC ATA | Intermediate | 9 | 3.48 (0 – 9.48) | 8 | 0.10 (0 – 7.56) | 0.077 |
  ACC ACC | Low | 6 | 4.05 (0 – 6.52) | 7 | 1.58 (0 – 4.92) | 0.221 |
  ACC ATA | Low | 3 | 2.99 (0.72 – 3.56) |  4 | 1.54 (0 – 6.74) | 0.721 |
  ATA ATA | Low | 6 | 4.92 (0.80 – 12.16) | 4 | 0.57 (0 – 5.13) | 0.087 |
  GCC haplotype | 23 | 3.56 (0 – 11.27) | 21 | 0.41 (0 – 7.56) | 0.001 | |
  ACC haplotype | 17 | 3.56 (0 – 7.16) | 17 | 1.48 (0 – 6.74) | 0.067 | |
  ATA haplotype | 18 | 3.56 (0 – 11.27) | 16 | 0.10 (0 – 7.56) | 0.011 | |
  −1082 G allele | 23 | 3.56 (0 – 11.27) | 21 | 0.48 (0 – 7.56) | <0.0001 | |
     A allele | 32 | 3.58 (0 – 12.16) | 29 | 1.09 (0 – 7.56) | <0.0001 | |
  −819  C allele | 32 | 3.56 (0 – 11.27) | 32 | 1.22 (0 – 7.56) | <0.0001 | |
     T allele | 18 | 4.50 (0 – 12.16) | 16 | 0.10 (0 – 7.56) | 0.002 | |
−592 C allele | 32 | 3.56 (0 – 11.27) | 32 | 1.22 (0 – 7.56) | <0.0001 | |
     A allele | 18 | 4.50 (0 – 12.16) | 16 | 0.10 (0 – 7.56) | 0.002 | |
TGF-β1 | ||||||
  TT GG | High | 14 | 18.98 (0 – 253.84) | 13 | 10.34 (2.67 – 19.34) | 0.058 |
  TC GG | High | 17 | 9.7 (0.16 – 185.28) | 12 | 10.23 (5.27 – 21.21) | 0.929 |
  TC GC | Intermediate | 3 | 12.95(3.44 – 70.94) |  5 | 8.04 (3.96 – 37.15) | 0.881 |
  CC GG | Intermediate | 3 | 6.32 (4.5 – 13.72) |  5 | 10.58 (6.06 – 13.19) | 0.655 |
  TT GC | Intermediate |  | - |  | - |  |
  CC GC | Low | 1 | 16.35 |  1 | 6.91 | 0.317 |
  CC CC | Low |  | - |  | - |  |
  TT CC | Low |  | - |  | - |  |
  TC CC | Low |  | - |  | - |  |
  Codon 10 T allele | 34 | 14.87 (0 – 253.84) | 30 | 10.34 (2.67 – 37.15) | 0.023 | |
      C allele | 24 | 11.32 (0.16 – 185.28) | 23 | 10.11 (3.96 – 37.15) | 0.949 | |
  Codon 25 G allele | 38 | 13.33 (0 – 253.84) | 23 | 10.34 (2.67 – 37.15) | 0.067 | |
      C allele | 4 | 14.65 (3.44 – 70.94) | 19 | 7.47 (3.96 – 37.15) | 0.670 | |