Skip to main content

Table 7 Association of IL-10 and TGF-β 1 polymorphisms with physiological parameters and HRCT scores in IPF patients

From: Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis

Cytokine/genotype/

†p-value

Allele

PaO2

FVC, % P

DLco,% P

Total extent

GGO

Retic

HC

AD

Emphy

IL-10 (−1082, -819, -592)

  GCC GCCa

0.389

0.262

0.948

0.098

0.137

0.935

0.514

0.334

0.173

  GCC ACCb

0.583

0.286

0.411

0.278

0.552

0.853

0.619

0.171

0.778

  GCC ATAc

0.390

0.905

0.710

0.564

0.741

0.942

0.501

0.539

0.962

  ACC ACCd

0.252

0.456

0.531

0.437

0.341

0.536

0.658

0.884

0.460

  ACC ATAe

0.533

0.354

0.390

0.171

0.837

0.069

0.014*

0.081

0.388

  ATA ATAf

0.319

0.730

0.058

0.695

0.837

0.147

0.203

0.820

0.635

  ANOVA

0.587

0.661

0.469

0.333

0.698

0.416

0.173

0.393

0.719

  GCC haplotypeg

0.606

0.472

0.517

0.497

0.120

0.415

0.769

0.681

0.333

  ACC haplotypeh

0.312

0.293

0.030*

0.329

0.080

0.326

0.440

0.767

0.101

  ATA haplotypei

0.018*

0.862

0.097

0.802

0.799

0.858

0.769

0.907

0.783

  −1082 G allelej

0.461

0.499

0.830

0.438

0.144

0.876

0.996

0.881

0.200

     A allele

  −819  C allelek

0.053

0.841

0.066

0.941

0.914

0.542

0.617

0.793

0.988

     T allele

  −592 C allelel

0.053

0.841

0.066

0.941

0.914

0.542

0.617

0.793

0.988

     A allele

TGF-β1(codons 10 and 25)

  TT GGm

0.902

0.161

0.548

0.690

0.462

0.708

0.734

0.839

0.711

  TC GGn

0.967

0.290

0.663

0.509

0.017*

0.708

0.734

0.892

0.951

  TC GCo

0.041*

0.119

0.217

0.876

0.240

0.528

0.270

0.732

0.444

  CC GGp

0.009*

0.372

0.526

0.037*

0.238

0.201

0.146

0.248

0.314

  TT GC

  CC GCq

0.128

0.858

0.101

0.412

0.020*

0.291

0.074

0.059

0.945

  CC CCr

0.911

0.083

0.539

0.451

0.090

0.403

0.533

0.122

0.050

  TT CC

  TC CC

  ANOVA

0.025*

0.157

0.408

0.359

0.010*

0.586

0.246

0.210

0.382

  Codon 10 T alleles

0.662

0.076

0.441

0.315

0.319

0.543

0.701

0.760

0.738

       C allele

 

  Codon 25 G allelet

0.021*

0.687

0.027*

0.890

0.053

0.726

0.968

0.800

0.370

       C allele

  1. Abbreviations: IL interleukin, TGF- β 1 transforming growth factor beta, HRCT high-resolution computed tomography, IPF idiopathic pulmonary fibrosis, PaO 2 partial pressure of oxygen, FVC,% P forced vital capacity, percent predicted, DLco diffusion capacity of the lung for carbon monoxide, GGO ground glass opacity, Retic reticulation, HC honeycombing, AD architectural distortion, Emphy emphysema.
  2. † One-way analysis of variance (ANOVA) and the Student’s t-test were used to compare the means of quantitative variables.
  3. * Statistically significant.
  4. aGCC GCC vs. other IL-10 genotypes.
  5. bGCC ACC vs. other IL-10 genotypes.
  6. cGCC ATA vs. other IL-10 genotypes.
  7. dACC ACC vs. other IL-10 genotypes.
  8. eACC ATA vs. other IL-10 genotypes.
  9. fATA ATA vs. other IL-10 genotypes.
  10. gGCC vs. other IL-10 haplotypes.
  11. hACC vs. other IL-10 haplotypes.
  12. iATA vs. other IL-10 haplotypes.
  13. jG vs. A allele.
  14. kC vs. T allele.
  15. lC vs. A allele.
  16. mTT GG vs. other TGF-β1 genotypes.
  17. nTC GG vs. other TGF-β1 genotypes.
  18. oTC GC vs. other TGF-β1 genotypes.
  19. pCC GG vs. other TGF-β1 genotypes.
  20. qCC GC vs. other TGF-β1 genotypes.
  21. rCC CC vs. other TGF-β1 genotypes.
  22. sT vs. C allele.
  23. tG vs. C allele.
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us