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Table 5 Comparison of genotype and allele frequencies for TGF-β 1 in IPF patients and healthy controls

From: Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis

Cytokine/genotype/allele

IPF (n = 60)

Healthy controls (n = 150)

*p-value

OR

95% CI

 TGF-β1 (codons 10 and 25)

     

 TT GGa

24 (40)

47 (31.3)

0.260

0.684

0.368 – 1.274

 TC GGb

24 (40)

53 (35.3)

0.530

0.820

0.443 – 1.517

 TC GCc

3 (5)

15 (10)

0.289

2.111

0.588 – 7.575

 CC GGd

5 (8.3)

27 (18)

0.091

2.415

0.883 – 6.602

 TT GC

0

0

-

  

 CC GCe

3 (5)

7 (4.7)

0.918

0.930

0.232 – 3.723

 CC CCf

1 (1.7)

1 (0.7)

0.500

0.396

0.024 – 6.435

 TT CC

0

0

-

  

 TC CC

0

0

-

  

 Codon 10

T alleleg

75 (62.5)

162 (54)

0.128

1.420

0.920 – 2.191

 

C allele

45 (37.5)

138 (46)

   

 Codon 25

G alleleh

112 (93.3)

276 (92)

0.839

1.217

0.531 – 2.791

 

C allele

8 (6.7)

24 (8)

   
  1. Data are presented as number (with percentages).
  2. Abbreviations: TGF-β 1 transforming growth factor beta, IPF idiopathic pulmonary fibrosis, OR odds ratio, CI confidence interval;
  3. *Chi-square or Fisher’s exact tests were used to compare frequencies between genotypes and alleles.
  4. aTT GG vs. other TGF-β1 genotypes.
  5. bTC GG vs. other TGF-β1 genotypes.
  6. cTC GC vs. other TGF-β1 genotypes.
  7. dCC GG vs. other TGF-β1 genotypes.
  8. eCC GC vs. other TGF-β1 genotypes.
  9. fCC CC vs. other TGF-β1 genotypes.
  10. gT vs. C allele.
  11. hG vs. C allele.